Zhuang-Gu-Fang Treats Osteoporosis in Ovariectomized Rats by Increasing the Osteogenesis-Related Factors Leptin, Ghrelin, and PYY

Figure 2

Zhuang-Gu-Fang improves bone structure and osteoblast ultrastructure in ovariectomized rats. (a) HE staining of the tibia bone (×400) of (A) sham operation Wistar rats of the same age which were taken as the negative control (NC) group, (B) model control (MC), (C) estradiol valerate 10 μg/kg per day as the positive control (PC), (D) Zhuang-Gu-Fang low dose (LD), (E) Zhuang-Gu-Fang medium dose (MD), and (F) Zhuang-Gu-Fang high dose (HD) after 3 months of treatment. (b) The osteoblasts ultrastructures were observed by electronic transmission microscopy. These osteoblasts were obtained in (A) NC, (B) MC, (C) PC, (D) LD, (E) MD, and (F) HD groups after 3 months of treatment.

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