Molecular Targets and Pathways Contributing to the Effects of Wenxin Keli on Atrial Fibrillation Based on a Network Pharmacology Approach

Figure 2

Drug-compound-target network of potential targets in WXKL. Blue diamond represents potential active ingredients in WXKL, compounds in WXKL are shown in light yellow, pink, red, orange, and purple, and the herbs are shown in green. Radix (Dang Shen, DS), Polygonati Rhizoma (Huang Jing, HJ), Notoginseng Radix et Rhizoma (San Qi, SQ), Ambrum (Hu Po, HP), and Nardostachyos Radix et Rhizoma (Gan Song, GS). A1 represents stigmasterol. A2 represents Diop. B1 represents beta-sitosterol. B2 represents sitosterol. DS1 represents daturilin. DS2 represents (8 S, 9 S, 10 R, 13 R, 14 S, 17 R)-17-[(E, 2 R, 5 S)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-1,2,4,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one. DS3 represents ZINC03978781. DS4 represents poriferasta-7,22E-dien-3beta-ol. DS5 represents spinasterol. DS6 represents stigmast-7-enol. DS7 represents 11-hydroxyrankinidine. DS8 represents 3-beta-hydroxymethyllenetanshiquinone. DS9 represents frutinone A. DS10 represents 7-(beta-xylosyl)cephalomannine_qt. DS11 represents perlolyrine. DS12 represents methyl icosa-11,14-dienoate. DS13 represents 7-methoxy-2-methyl isoflavone. DS14 represents luteolin. DS15 represents glycitein. GS1 represents cryptotanshinone. GS2 represents acacetin. GS3 represents (2R)-5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one. HJ1 represents diosgenin. HJ2 represents (+)-syringaresinol-O-beta-D-glucoside. HJ3 represents baicalein. HJ4 represents 4′,5-dihydroxyflavone. HJ5 represents 3′-methoxydaidzein. SQ1 represents ginsenoside rh2. SQ2 represents quercetin. SQ3 represents mandenol.