Chemopreventive Effects and Antioxidant Capacity of Combined Leaf Extracts of Sesamum angustifolium (Oliv.) Engl. and Hibiscus articulatus on Rhabdomyosarcoma

Table 2

Cell viability of RD and L20B cells after 48-hour treatment with SAHA extracts and doxorubicin.

SAHA extract	Concentration (μg/mL)	Cell viability (%)
		RD cells	L20B cells
Dichloromethane	200	39.5 ± 5.1^a	64.5 ± 4.1
Dichloromethane	100	45.4 ± 9.7^a	71.4 ± 6.0
Dichloromethane	50	47.1 ± 5.7^a	72.0 ± 8.6
Dichloromethane	25	63.1 ± 4.6	78.2 ± 5.8
Dichloromethane	12.5	77.0 ± 7.3	85.6 ± 2.1
Acetone	200	43.4 ± 4.9^a	68.4 ± 7.2
Acetone	100	61.6 ± 3.5	72.3 ± 9.2
Acetone	50	73.3 ± 7.3	74.4 ± 12.1
Acetone	25	79.2 ± 5.6	74.3 ± 10.2
Acetone	12.5	84.3 ± 5.5	92.9 ± 5.7
Methanol	200	40.0 ± 6.2^a	79.3 ± 4.4
Methanol	100	48.3 ± 5.6^a	80.6 ± 8.9
Methanol	50	64.1 ± 3.5	86.0 ± 5.0
Methanol	25	63.8 ± 6.3	86.2 ± 3.0
Methanol	12.5	76.6 ± 10.1	89.7 ± 4.8
Aqueous	200	41.4 ± 3.0^a	62.5 ± 1.8
Aqueous	100	50.7 ± 1.6^a	63.2 ± 3.8
Aqueous	50	58.9 ± 5.8^a	66.9 ± 4.5
Aqueous	25	74.3 ± 4.0	70.3 ± 2.7
Aqueous	12.5	83.6 ± 1.3	79.4 ± 8.6
Doxorubicin	8	30.5 ± 2.4^a	59.2 ± 7.5
Doxorubicin	4	34.2 ± 4.1^a	71.0 ± 9.4
Doxorubicin	2	40.1 ± 5.4^a	73.9 ± 6.1
Doxorubicin	1	44.4 ± 6.8^a	77.5 ± 10.0
Doxorubicin	0.5	57.2 ± 11.1^a	81.9 ± 5.3

The number of live negative control cells (0 μg/mL) at 48 h was used as 100% viability, so all cells were expressed as a percentage of them. Results are expressed as mean ± SD (n = 3). a and b represents significant difference (), compared to untreated RD and L20B cells, respectively. indicates and indicates when comparing RD cells to L20B cells.