The Metabolomic Rationale for Treating Perimenopausal Syndrome as Kidney Deficiency

Figure 5

Treatment with Yougui. (a) Yougui altered the metabolic profile of perimenopausal rats. The red dots were from rats treated with saline, while green ones were from rats treated with Yougui. The two groups of rats were of the same age, and the difference in PLS-DA analysis indicated that Yougui perturbed the metabolism of rats. (b) PLS-DA analysis of metabolites from the plasma of Yougui-treated rats (green) in reference to that of rats in the early phase of perimenopause (red) indicated that Yougui modulated the metabolic profile of rats towards that of rats at younger age. (c) The metabolome of the Yougui-treated rats (green) was still distinct from that of rats that had not entered the perimenopausal period (red). (d) The level of lipid was significantly downregulated by Yougui to the levels of rats at 6 months old. The level of glucose and other metabolites in the TCA cycle was significantly upregulated. Importantly, the plasma level of trimethylamine-n-oxide was lowered to that of rats of much younger age. ; .

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