HPLC-MS/MS Analysis of Aconiti Lateralis Radix Praeparata and Its Combination with Red Ginseng Effect on Rat CYP450 Activities Using the Cocktail Approach

Figure 2

Mean plasma concentration-time curves of probe drugs in different groups (mean ± SD, n = 6). Group A received 10 mL/kg cocktail solution through the tail vein; group B received 0.415 g/kg Aconiti Lateralis Radix Praeparata extract by oral administration for 7 consecutive days and dosed 10 mL/kg cocktail solution through the tail vein on the eighth day; group C received 0.415 g/kg Aconiti Lateralis Radix Praeparata extract and 2.34 g/kg red ginseng extract by oral administration for 7 consecutive days and dosed 10 mL/kg cocktail solution through the tail vein on the eighth day. (a) 7-Hydroxycoumarin. (b) Omeprazole. (c) Dextromethorphan. (d) Bupropion. (e) Phenacetin. (f) Dapsone. (g) Tolbutamide. (h) Amodiaquine.

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