HPLC-MS/MS Analysis of Aconiti Lateralis Radix Praeparata and Its Combination with Red Ginseng Effect on Rat CYP450 Activities Using the Cocktail Approach

Table 1

MS parameters of the eight probe drugs and IS.

Probe drug	Precursor ion (m/z)	Product ion (m/z)	Frag. (V)	C.E. (V)
Omeprazole	346.2	136.1	75	35
Dapsone	249.1	92.1	125	21
Dextromethorphan	272.2	147.1	115	30
Phenacetin	180.1	110.1	105	20
Tolbutamide	271.1	91.0	80	30
Bupropion	240.1	184.1	85	7
Amodiaquine	356.2	283.1	96	15
7-Hydroxycoumarin	163.0	107.1	95	20
Diazepam (IS)	285.0	193.0	105	30