HPLC-MS/MS Analysis of Aconiti Lateralis Radix Praeparata and Its Combination with Red Ginseng Effect on Rat CYP450 Activities Using the Cocktail Approach

Table 2

The calibration curves and LLOQs of the eight probe drugs.

Probe drug	Regression equation	Correlation coefficients (r)	Linear range (ng/mL)	LLOQ (ng/mL)
7-Hydroxycoumarin	y = 0.185218x + 0.003722	0.9964	10–5000	2
Omeprazole	y = 0.952998x + 0.015885	0.9920	4–2000	1
Dextromethorphan	y = 0.888828x + 0.008993	0.9919	1–500	1
Bupropion	y = 1.871081x + 0.001977	0.9910	2–1000	1
Phenacetin	y = 1.442258x + 0.009962	0.9919	2–1000	1
Dapsone	y = 0.376316x + 0.001369	0.9961	1–500	1
Tolbutamide	y = 0.499142x + 0.004604	0.9984	6–3000	1
Amodiaquine	y = 1.707230x + 0.230893	0.9937	2–1000	1