HPLC-MS/MS Analysis of Aconiti Lateralis Radix Praeparata and Its Combination with Red Ginseng Effect on Rat CYP450 Activities Using the Cocktail Approach
Table 6
Pharmacokinetic parameters of the eight probe drugs in different groups (n = 6).
Probe drug
Group
Cmax (ng/mL)
t1/2 (h)
AUC(0-24) (h·ng/mL)
AUC(0-∞) (h·ng/mL)
MRT(0-24) (h)
MRT(0-∞) (h)
7-Hydroxycoumarin
Group A
3310.91 ± 348.65
0.03 ± 0.01
212.41 ± 38.95
214.88 ± 39.27
0.06 ± 0.02
0.09 ± 0.06
Group B
5360.83 ± 701.87∗∗
0.03 ± 0.01
387.45 ± 68.22∗∗
394.89 ± 68.81∗∗
0.10 ± 0.06
0.17 ± 0.14
Group C
4932.90 ± 675.99
0.03 ± 0.01
355.16 ± 84.91
361.22 ± 83.06
0.08 ± 0.02
0.17 ± 0.22
Omeprazole
Group A
987.61 ± 72.73
0.15 ± 0.03
252.70 ± 43.54
256.31 ± 43.28
0.32 ± 0.07
0.36 ± 0.11
Group B
1286.26 ± 151.01∗∗
0.02 ± 0.02∗∗
372.49 ± 71.09∗∗
386.43 ± 72.30∗∗
0.46 ± 0.16
0.59 ± 0.27
Group C
1574.58 ± 170.41#
0.02 ± 0.01
337.91 ± 62.29
342.83 ± 60.77
0.31 ± 0.05
0.34 ± 0.04
Dextromethorphan
Group A
172.16 ± 13.69
0.42 ± 0.09
156.08 ± 26.13
161.46 ± 29.28
1.51 ± 0.26
1.74 ± 0.33
Group B
165.50 ± 15.41
0.41 ± 0.03
171.04 ± 31.51
176.99 ± 35.12
2.06 ± 0.76
2.58 ± 1.49
Group C
248.50 ± 19.2 9##
0.03 ± 0.02##
290.03 ± 38.27##
340.32 ± 92.03##
3.35 ± 0.89#
10.28 ± 11.90
Bupropion
Group A
138.32 ± 28.61
0.22 ± 0.11
67.70 ± 11.50
69.72 ± 11.44
1.01 ± 0.16
1.20 ± 0.23
Group B
149.44 ± 29.54
0.25 ± 0.13
85.71 ± 14.43∗
88.31 ± 14.45∗
1.09 ± 0.18
1.29 ± 0.23
Group C
384.52 ± 73.86##
0.11 ± 0.05#
139.45 ± 28.21##
141.53 ± 28.29##
0.94 ± 0.06
1.03 ± 0.08#
Phenacetin
Group A
495.83 ± 36.15
0.13 ± 0.02
116.03 ± 17.62
118.18 ± 17.65
0.28 ± 0.06
0.30 ± 0.08
Group B
743.88 ± 71.09∗∗
0.13 ± 0.03
187.04 ± 35.84∗∗
190.07 ± 34.61∗∗
0.34 ± 0.03∗
0.38 ± 0.08
Group C
689.54 ± 59.76
0.03 ± 0.02##
141.09 ± 27.32#
143.90 ± 27.08#
0.31 ± 0.05
0.34 ± 0.04
Dapsone
Group A
458.48 ± 60.11
0.04 ± 0.03
1347.37 ± 179.94
1369.79 ± 184.98
4.73 ± 0.47
5.14 ± 0.61
Group B
535.58 ± 42.55∗
0.27 ± 0.27
2400.17 ± 561.81∗∗
2497.74 ± 588.53∗∗
6.01 ± 0.78∗∗
7.02 ± 1.43∗
Group C
565.45 ± 40.30
0.03 ± 0.02
1291.00 ± 254.39##
1312.41 ± 272.61##
4.70 ± 0.66#
5.07 ± 0.97#
Tolbutamide
Group A
2144.68 ± 97.44
0.09 ± 0.06
15770.98 ± 1759.31
17824.22 ± 2236.80
7.72 ± 0.31
10.91 ± 1.03
Group B
3457.97 ± 177.28∗∗
0.10 ± 0.08
21745.37 ± 3425.25∗∗
32421.98 ± 9258.81∗
8.85 ± 0.64∗∗
21.88 ± 13.86
Group C
2616.79 ± 105.40##
0.06 ± 0.02
11848.93 ± 1187.25##
12767.39 ± 1304.87##
7.02 ± 0.22##
8.92 ± 0.47#
Amodiaquine
Group A
143.49 ± 12.30
0.04 ± 0.03
177.26 ± 50.00
196.00 ± 57.29
5.69 ± 1.12
8.23 ± 2.14
Group B
127.07 ± 19.29
0.07 ± 0.03
138.39 ± 60.47
157.45 ± 60.55
4.16 ± 2.28
6.23 ± 3.19
Group C
216.91 ± 43.19##
0.02 ± 0.03#
189.37 ± 18.90
235.24 ± 71.91
5.84 ± 0.83
12.49 ± 8.33
, B different from group A; , B significantly different from group A. , C different from group B;, C significantly different from group B.
