In Vivo Antiplasmodial Activity of Different Solvent Extracts of Myrianthus libericus Stem Bark and Its Constituents in Plasmodium berghei-Infected Mice
Table 7
Effect of ML1 and ML2 on body weight and PCV in the suppressive test.
Dose (mg·kg−1)
Body weight (g)
Packed cell volume
Day 0
Day 4
W
Day 0
Day 4
PCV
NC
21.53 ± 0 .41
17.63 ± 0.69a2
−3.9
53.03 ± 1.08
48.86 ± 0.67a1
−4.17
ML1
10
21.80 ± 0.569
19.20 ± 0.21
−2.6
51.40 ± 0.81
49.60 ± 0.40
−1.8
20
22.33 ± 0.731
20.53 ± 0.63
−1.8
54.33 ± 1.42
53.30 ± 0.47
−1.03
30
21.40 ± 1.22
20.93 ± 0.56
−0.47
52.63 ± 0.97
51.70 ± 0.92
−0.93
ML2
10
23.03 ± 0.83
20.00 ± 0.50a1
−3.03
53.37 ± 1.71
49.23 ± 0.58a1
−4.14
20
22.10 ± 1.28
21.37 ± 0.18
−0.73
55.87 ± 0.89
53.37 ± 0.84
−2.5
30
22.28 ± 0.83
21.87 ± 0.15
−0.41
55.23 ± 1.19
54.17 ± 0.55
−1.06
ART
2
20.93 ± 0.81
19.17 ± 0.30
−1.76
56.17 ± 1.07
55.50 ± 0.47
−0.67
Values are presented as mean ± SEM, n = 6. NC = vehicle-treated group; ART = artesunate. Values are significant at and , acompared to day 0.
