In Vivo Antiplasmodial Activity of Different Solvent Extracts of Myrianthus libericus Stem Bark and Its Constituents in Plasmodium berghei-Infected Mice

Table 8

Parasitaemia level, % suppression, and mean survival time of P. berghei-infected mice treated with ML1 and ML2 in the curative test.

Dose (mg·kg^−1)		% parasitaemia		% suppression	Mean survival time (days)
		Day 3	Day 7
NC		43.70 ± 1.79	70.80 ± 2.01^a4	—	6.00 ± 0.93
ML1	10	40.38 ± 1.51	37.39 ± 0.22^b4	47.19	10.50 ± 0.72^b1
	20	40.28 ± 1 .72	28.95 ± 1.29^a4,b4	59.11	11.83 ± 0.30^b3
	30	41.63 ± 0.76	20.78 ± 1.13^a4,b4	70.64	20.50 ± 0.56^b4
ML2	10	41.29 ± 0.54	37.56 ± 0.42	46.95	9.83 ± 0.31
	20	42.16 ± 1.92	30.64 ± 0.67^a4,b4	56.72	11.50 ± 0.72^b3
	30	41.97 ± 0.94	27.52 ± 0.89^a4,b4	61.13	19.67 ± 0.49^b4
ART	2	40.06 ± 2.13	1.26 ± 0.10^a4,b4	98.22	29.67 ± 0.33^b4

Values are presented as mean ± SEM, n = 6. NC: vehicle-treated group; ART: artesunate. Values are significantly different at , , and , ^acompared to day 3, ^bcompared to negative control.