A Phase II Pilot Trial to Evaluate CoBaT-Y017 Safety and Efficacy against Uncomplicated Falciparum Malaria versus Artemether-Lumefantrine in Benin Subjects

Table 1

Evolution of the positive thick blood film and the parasite density in the two arms of study at different days of visit.

Biological characteristics	Day	AL group	CoBaT-Y017 group	value
		Proportion or mean (± std)	Proportion or mean ( ± std)
Positive thick blood film	D1	100%	100%
	D2	75%	46.2%	0.14
	D3	33.3%	23.1%	0.67
	D4	—	15.4%
	D5	—	—
	D7	—	—
	D14	—	—
	D21	—	—
	D28	—	—
Parasite density	D1	14482.4 (±7888)	17832.4 (±28442)	0.77
	D2	6375.3 (±17689)	4335.5 (±9385)	0.72
	D3	172.6 (±352)	1785.2 (±4846.4)	0.26
	D4		367.3 ((±1131)	—
	D5	—	—
	D7	—	—
	D14	—	—
	D21	—	—
	D28	—	—

Fisher’s exact nonparametric test; D4-positive parasitaemia was only observed in the CoBaT-Y017 group; —: negative thick blood film.