Clinical Efficacy and Safety of Thai Herbal Formulation-6 in the Treatment of Symptomatic Osteoarthritis of the Knee: A Randomized-Controlled Trial

Table 1

Demographic and clinical characteristics of the enrolled patients.

	THF-6 (n = 100)	Diclofenac (n = 100)
Age (years)	62.0 ± 6.1	60.3 ± 6.1
Female sex (%)	87	84
BMI (kg/m^2)	26.0 ± 4.7	25.7 ± 6.3^a
Location of osteoarthritis (n)
Right knee	9	7
Left knee	5	7
Both knees	86	86
Kellgren–Lawrence grade (n)
Grade 2	62	68
Grade 3	68	73
Grade 4	56	45
Duration of osteoarthritis of the knee (years)	4.9 ± 4.7	4.7 ± 4.3
Underlying disease (n)
Hypertension	43	50
Dyslipidemia	27	30
Diabetes mellitus	13	12
Miscellaneous	7	12
None	49	37
Baseline measures
VAS pain (mm)	60.0 ± 14.8	61.9 ± 15.7
VAS stiffness (mm)	54.9 ± 20.2	56.9 ± 22.3
KOOS
Pain	49.5 ± 14.3	51.4 ± 17.1
Other knee symptoms	55.2 ± 15.3	53.7 ± 18.3
Activities of daily living	51.3 ± 16.7	53.3 ± 18.3
Sport and recreation function	24.4 ± 19.4	26.8 ± 20.4
Knee-related quality of life	32.1 ± 15.8	32.0 ± 17.6
SCT (sec)	12.1 ± 5.9	11.5 ± 5.6

^an = 99. KOOS, Knee Injury and Osteoarthritis Outcome Score; SCT, 10-step stair climb test; VAS, visual analog scale.