Evidence-Based Complementary and Alternative Medicine

Research Article

Adjuvant Fuzheng Huayu Capsule Reduces the Incidence of Hepatocellular Carcinoma in Patients with Hepatitis B-Caused Cirrhosis

Table 2

Clinical characteristics of patients with hepatitis B-caused cirrhosis before and after propensity score matching.


Variable	Before propensity matching			After propensity matching
Variable	TCM user (n = 270)	Non-TCM users (n = 572)	value	TCM user (n = 259)	Non-TCM users (n = 259)	value

Age, years	50.0 (42.0, 59.0)	50.0 (42.0, 58.0)	0.525	50.0 (42.0, 59.0)	49.0 (42.0, 58.0)	0.234
Male sex, n (%)	191 (70.7%)	393 (68.7%)	0.550	184 (71.0%)	168 (64.8%)	0.132
Family history of HCC, n (%)	19 (7.0%)	33 (5.8%)	0.476	18 (6.9%)	16 (6.2%)	0.723
Smoking, n (%)	61 (22.6%)	128 (22.4%)	0.944	58 (22.4%)	58 (22.4%)	1.000
Alcohol consumption, n (%)	41 (15.2%)	85 (14.9%)	0.984	39 (15.1%)	39 (15.1%)	1.000
Diabetes, n (%)	57 (21.1%)	85 (14.9%)	0.024	53 (20.5%)	49 (18.9%)	0.659
Hypertension, n (%)	55 (20.4%)	80 (13.9%)	0.018	50 (19.3%)	44 (16.9%)	0.494
Ascites, n (%)	46 (17.0%)	77 (13.4%)	0.170	45 (17.3%)	41 (15.8%)	0.637
Hepatic encephalopathy, n (%)	14 (5.2%)	18 (3.1%)	0.149	14 (5.4%)	10 (3.9%)	0.403
Gastroesophageal varices, n (%)	69 (25.5%)	137 (23.9%)	0.613	65 (25.1%)	81 (31.3%)	0.118
HBeAg positivity, n (%)	143 (52.9%)	296 (51.7%)	0.818	139 (53.6%)	126 (48.6%)	0.206
CTP score, n (%)	8.0 (6.0, 10.0)	8.0 (6.0, 10.0)	0.837	8.0 (6.0, 10.0)	8.0 (6.0, 10.0)	0.130
MELD score, n (%)	10.3 (8.2, 13.2)	10.3 (8.3, 12.9)	0.822	10.3 (8.3, 13.2)	10.7 (8.4, 13.6)	0.573
Alanine aminotransferase, U/L	37.9 (24.1, 80.2)	36.4 (24.0, 76.5)	0.744	37.7 (24.1, 78.3)	37.0 (27.2, 114.5)	0.139
Aspartate aminotransferase, U/L	43.3 (30.8, 76.7)	42.9 (29.1, 85.3)	0.622	43.3 (31.5, 76.5)	46.5 (31.9, 111.0)	0.132
Total bilirubin, μmol/L	27.1 (18.6, 44.8)	23.7 (14.6, 39.7)	0.004	27.2 (18.9, 44.6)	29.5 (16.7, 48.0)	0.838
Albumin, g/L	32.2 (27.9, 37.1)	32.2 (27.7, 37.5)	0.798	32.4 (27.9, 37.0)	32.2 (27.4, 36.4)	0.329
Gamma-glutamyl transferase, U/L	50.3 (24.7, 90.9)	35.7 (20.3, 83.9)	0.010	50.0 (24.9, 90.8)	38.5 (20.8, 85.1)	0.102
White blood cell count, ×10⁹/L	4.2 (3.2, 5.4)	3.6 (2.6, 5.1)	0.001	4.0 (3.1, 5.3)	3.8 (2.7, 5.7)	0.278
Platelets, ×10⁹/L	71.0 (50.4, 101.0)	68.0 (47.2, 99.0)	0.715	71.0 (50.0, 101.0)	69.8 (51.8, 101.0)	0.731
Creatinine, μmol/L	64.0 (53.0, 73.4)	65.9 (56.3, 75.0)	0.027	64.4 (53.5, 73.9)	63.0 (55.0, 72.0)	0.737
Blood urea nitrogen, mmol/L	5.2 (4.2, 6.8)	5.8 (4.1, 6.9)	0.644	5.2 (4.2, 6.9)	5.2 (3.8, 6.8)	0.367
International normalized ratio	1.2 (1.1, 1.3)	1.2 (1.1, 1.4)	0.673	1.2 (1.1, 1.3)	1.2 (1.1, 1.3)	0.726
Prothrombin activity,%	61.0 (50.0, 76.0)	60.0 (48.0, 68.0)	0.021	61.0 (50.0, 76.0)	61.0 (50.0, 73.0)	0.811
Alpha-fetoprotein, ng/ml	10.0 (4.0, 64.4)	6.4 (3.2, 33.0)	0.006	10.0 (4.0, 63.5)	9.0 (4.2, 47.9)	0.926
HBV DNA, log₁₀IU/ml	4.2 (2.7, 5.7)	3.8 (2.7, 5.6)	0.118	4.1 (2.7, 5.7)	4.0 (2.7, 5.7)	0.881

Data are presented as n (%) or median (interquartile range). CTP: Child-Turcotte-Pugh; MELD: Model for End-Stage Liver Disease.