Hypotensive and Antihypertensive Properties and Safety for Use of Annona muricata and Persea americana and Their Combination Products
Table 3
Effect of 50, 75, and 100 mg/kg CAPE and nifedipine on full blood count.
Parameter
Combined extract (mg/kg)
0.5 mg/kg nifedipine
Negative control
Normal control
50 CAPE 1
75 CAPE 2
100 CAPE 1
WBC (×103/uL)
10.03 ± 1.25
9.08 ± 0.51
14.60 ± 0.32
11.48 ± 1.36
10.10 ± 0.79
12.60 ± 0.20
RBC (×106/uL)
8.16 ± 0.30
7.77 ± 0.56
8.01 ± 0.14
8.02 ± 0.30
8.16 ± 0.17
7.70 ± 0.14
HGB (g/dL)
14.73 ± 0.86
13.96 ± 1.02
14.14 ± 0.17
14.30 ± 0.11
14.35 ± 0.16
13.95 ± 0.65
HCT (%)
45.03 ± 1.48
42.86 ± 3.63
44.66 ± 1.28
43.40 ± 1.58
44.98 ± 0.41
44.25 ± 0.95
MCV (fL)
55.22 ± 0.70
54.96 ± 1.14
55.72 ± 0.97
54.15 ± 0.59
55.23 ± 0.85
57.50 ± 0.20
MCH (pg)
18.02 ± 0.53
17.98 ± 0.36
17.68 ± 0.26
17.93 ± 0.58
17.63 ± 0.48
18.10 ± 0.50
MCHC (g/dL)
32.62 ± 0.58
32.74 ± 0.51
31.72 ± 0.65
33.08 ± 1.05
31.90 ± 0.41
31.50 ± 0.80
PLT (×103/uL)
614.17 ± 90.97
802.20 ± 78.86
668.00 ± 77.60
700.25 ± 118.89
693.50 ± 92.47
635.00 ± 30.00
LYM%
65.40 ± 2.61
69.74 ± 3.01
65.64 ± 2.52
67.05 ± 1.88
66.05 ± 1.86
69.50 ± 0.30
LYM# (×103/uL)
6.58 ± 0.92
6.30 ± 0.39
9.56 ± 0.33
7.75 ± 1.12
6.68 ± 0.57
8.75 ± 0.05
RDW_SD (fL)
29.08 ± 0.65
26.56 ± 3.39
30.48 ± 0.66
30.70 ± 1.19
29.13 ± 0.63
29.70 ± 1.40
RDW_CV (%)
14.73 ± 0.70
13.10 ± 0.97
14.10 ± 0.72
16.03 ± 1.95
13.35 ± 0.93
12.50 ± 1.00
PDW (fL)
10.17 ± 0.20
10.16 ± 0.61
10.40 ± 0.74
10.73 ± 0.59
9.78 ± 0.09
9.90 ± 0.30
MPV (fL)
7.75 ± 0.13
8.90 ± 0.93
7.86 ± 0.29
7.63 ± 0.17
7.80 ± 0.17
7.65 ± 0.05
P_LCR (%)
11.77 ± 0.76
13.68 ± 0.26
13.24 ± 1.73
12.00 ± 0.98
12.10 ± 0.90
11.90 ± 0.60
Values are expressed as mean ± SEM (n = 5). Statistical analysis indicated no significant difference () (one-way ANOVA with Dunnett’s post hoc test). WBC: white blood cell; RBC: red blood cell; HGB: haemoglobin; HCT: haematocrit; MCV: mean cell volume; MCH: mean cell haemoglobin; MCHC: mean cell haemoglobin concentration; PLT: platelet; LYM: lymphocyte; RDW: red cell distribution width; SD: standard deviation; CV: coefficient of variation; PDW: platelet distribution width; MPV: mean platelet volume; P_LCR: platelet large cell ratio.
