So-Ochim-Tang-Gamibang, a Traditional Herbal Formula, Ameliorates Depression by Regulating Hyperactive Glucocorticoid Signaling In Vitro and In Vivo

Figure 5

Effects of SOCG on the expression of neuronal factors in the hippocampus. WKY rats were subjected to chronic restraint stress for 2 weeks, and SOCG was orally administered (300 mg/kg). The hippocampus was dissected from the rat brains and used for protein and mRNA purification. The levels of BDNF were measured by (a) western blot analysis and (b) real-time PCR. The levels of (c) phosphorylated CREB and (d) phosphorylated ERK were measured by western blotting analysis. The data are presented as the mean ± SEM. # and ##, significant difference compared to the naive group. and , significant difference compared to the control group. AMI: amitriptyline (10 mg/kg).

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