So-Ochim-Tang-Gamibang, a Traditional Herbal Formula, Ameliorates Depression by Regulating Hyperactive Glucocorticoid Signaling In Vitro and In Vivo

Figure 6

Effects of SOCG on the hippocampal GR and nNOS expression levels in WKY rats. The animals were subjected to chronic restraint stress for 2 weeks, and SOCG was orally administered (300 mg/kg). The hippocampal GR levels were measured by (a) western blotting analysis and (b) real-time PCR. (c) The hippocampal nNOS levels were measured by western blotting analysis. The data are presented as the mean ± SEM. GAPDH was used for the normalization of the expression levels of the target genes in the real-time PCR analysis. #, significant difference compared to the naive group. and , significant difference compared to the control group. AMI: amitriptyline (10 mg/kg).

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