Astragaloside IV Enhances Melanogenesis via the AhR-Dependent AKT/GSK-3β/β-Catenin Pathway in Normal Human Epidermal Melanocytes

Figure 7

A proposed mechanism of AS-IV-induced melanogenesis. Astragaloside IV activates AhR, which then induces the phosphorylation of AKT and GSK-3β to promote β-catenin nuclear translocation. β-Catenin binds the promoter of the MITF gene to increase MITF transcription and subsequently upregulates TYR, TRP-1, and TRP-2 expressions and ultimately stimulates the melanin synthesis.