A Network Pharmacology to Explore the Mechanism of Astragalus Membranaceus in the Treatment of Diabetic Retinopathy

Table 3

Specific information for core targets.

Number	Uniprot ID	Gene name	Protein name	Counts
1	P31749	AKT1	RAC-alpha serine/threonine-protein kinase	36
2	P15692	VEGFA	Vascular endothelial growth factor A	37
3	P05231	IL6	Interleukin-6	35
4	P42574	CASP3	Caspase-3	36
5	P12931	SRC	Proto-oncogene tyrosine-protein kinase Src	35
6	P00533	EGFR	Epidermal growth factor receptor	31
7	P28482	MAPK1	Mitogen-activated protein kinase 1	35
8	P40763	STAT3	Signal transducer and activator of transcription 3	35
9	P05412	JUN	Transcription factor AP-1	33
10	P01112	HRAS	GTPase HRas	35
11	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	32
12	P45983	MAPK8	Mitogen-activated protein kinase 8	32
13	P42345	MTOR	Serine/threonine-protein kinase mTOR	33
14	P24385	CCND1	G1/S-specific cyclin-D1	33
15	P03372	ESR1	Estrogen receptor	33
16	P09038	FGF2	Fibroblast growth factor 2	33
17	P14780	MMP9	Matrix metalloproteinase-9	33
18	P35354	PTGS2	Prostaglandin G/H synthase 2	33
19	P37231	PPARG	Peroxisome proliferator-activated receptor gamma	25
20	P42336	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	29
21	P10275	AR	Androgen receptor	29
22	P08253	MMP2	72 kDa type IV collagenase	29
23	P35968	KDR	Vascular endothelial growth factor receptor 2	25
24	Q09472	EP300	Histone acetyltransferase p300	27
25	P27986	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha	28
26	P60568	IL2	Interleukin-2	29
27	P12821	ACE	Angiotensin-converting enzyme	18
28	O60674	JAK2	Tyrosine-protein kinase JAK2	27
29	P05067	APP	Amyloid-beta precursor protein	23
30	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	30
31	P08069	IGF1R	Insulin-like growth factor 1 receptor	26
32	P05164	MPO	Myeloperoxidase	16
33	P23443	RPS6KB1	Ribosomal protein S6 kinase beta-1	27
34	P04150	NR3C1	Glucocorticoid receptor	21
35	P10721	KIT	Mast/stem cell growth factor receptor kit	23
36	P49841	GSK3B	Glycogen synthase kinase-3 beta	26
37	P11802	CDK4	Cyclin-dependent kinase 4	23
38	P00734	F2	Prothrombin	19