Research Article

Antidiarrheal Effect of Sechang-Zhixie-San on Acute Diarrhea Mice and Network Pharmacology Deciphering Its Characteristics and Potential Mechanisms

Table 3

Information of active compounds and potential targets.

IdCompoundsIAOBDLGene symbol

YT01Daucosterol++STAT3, EGFR, OPRM1, KIT, TNF, SLC, CYP3A4
YT02(E)-3, 7-Dimethyl-1-O-[α-L-rhamnopyranosyl-(1 ⟶ 6)-β-D-glucopyranosyl]-oct-2-en-7-olSTAT3, TNF, BTK, SLC5A1
YT037-Dimethyl-1-O-[α-L-arabinofuranosyl-(1 ⟶ 6)-β-D-glucopyranosyl]-oct-2-en-7-olSTAT3, EGFR, VEGFA, TNF, LCK, BTK, ACE, SLC5A1
YT04Geranyl-1-O-α-L-arabinopyranosyl-(1 ⟶ 6)-β-D-glucopyranoside+STAT3, EGFR, VEGFA, KIT, TNF, LCK, BTK, ACE, SLC5A1, SLC10A2
YT05Geranyl-1-O-β-D-xylopyranosyl-(1 ⟶ 6)-β-D-glucopyranoside+STAT3, EGFR, VEGFA, KIT, TNF, ACE, SLC5A1, SLC10A2
YT063α-O-(E)-p-Hydroxy-cinnamoyl-olean-12-en-27-oic acid+STAT3, EGFR, VEGFA, KIT, TNF, LCK, BTK, ACE, SLC5A1
YT073-O-Galloyl-epicatechin+STAT3
YT081-O-Galloyl-β-D-glucose+STAT3, OPRM1, VEGFA, ACE, VDR, ABCB11
YT09Anethole+++STAT3, EGFR, JAK3, ACE
YT10Myristic acid+VDR
YT113-Methoxy-4-O-D-glucopyranosyl- phenylpropane-7, 8, 9-triol+EGFR, LCK, ACE, SLC5A1
YT12Bergenin++EGFR
YT134-O-Galloylbergenin+EGFR, NRAS, VEGFA
YT1411-O-Galloylbergenin+EGFR, NRAS, VEGFA
YT15Quercetin++EGFR, PIK3R1
YT163, 4-Dihydroxybenzoic acid+++EGFR, OPRM1, LCK
YT17Benzene, 1, 2-dimethoxy-4-(1-propenyl)-+++EGFR, JAK3
YT18Rutin+OPRM1
YT19Ethyl gallate+++ADAM17
YT20Ergosterol++JAK3, OPRM1, VDR
YT21Geranyl 6-O-β-D-xylopyranosyl-β-D-glucopyranoside+SLC5A1
YT22Carvacrol+++JAK3
YT233, 3′, 4′, 5, 7-pentahydroxyflavan+VEGFA, KIT, LCK
YT243-O-β-Hydroxy-δ-8-β-(3, 4-dihydroxyphenyl)-pentanone++VEGFA, ACE
YT25Eugenol++VEGFA, JAK3
YT26β-Sitosterol++TNF, VDR, CYP3A4
YT276-O-Galloyl-D-glucose++TNF, ACE
YT28Oleanolic acid+++TNF
YT293, 5-Dimethoxy-4-O-β-D-glucopyranosyl-phenylpropane-7, 8, 9-TriolLCK, BTK, ACE, SLC5A1
YT30Arbutin+LCK, SLC5A1
YT31Stearic acid+ACE, VDR
YT32Citronellal+++ACE
YT33Hexadecanoic acid+VDR
YT34(−)-limonene+++VDR
YT35Lauric acid++VDR
YT36Geranyl-1-O-α-L-rhamnopyranosyl-(1 ⟶ 6)-β-D-glucopyranoside+TNF, STAT3, EGFR, VEGFA, NRAS, IL2, KIT, ADAM17, ACE

Note. OB : human oral bioavailability; IA : human intestinal absorption; DL : drug-likeness.