Acute and Subacute Toxicity Profiles of the Methanol Extract of Lycopersicon esculentum L. Leaves (Tomato), a Botanical with Promising In Vitro Anticancer Potential

Table 3

Organ weights (g) of the female and male rats in subacute toxicity of methanolic extract of L. esculentum.

Sexes	Organs	Control	L. esculentum extract doses (mg/kg)
			250	500	1000
Female	Liver (g)	3.56 ± 0.55^a	3.16 ± 0.12^a	3.03 ± 0.14^a	3.30 ± 0.26^a
	Kidneys (g)	0.70 ± 0.02^a	0.69 ± 0.03^a	0.61 ± 0.07^a	0.68 ± 0.08^a
	Spleen (g)	0.54 ± 0.1^a	0.45 ± 0.07^a	0.39 ± 0.03^a	0.49 ± 0.10^a
	Lung (g)	0.70 ± 0.16^a	0.74 ± 0.10^a	0.72 ± 0.08^a	0.75 ± 0.13^a
	Heart (g)	0.35 ± 0.03^a	0.32 ± 0.01^a	0.34 ± 0.03^a	0.33 ± 0.01^a
Male	Liver (g)	3.10 ± 0.10^a	3.05 ± 0.26^a	3.07 ± 0.12^a	3.08 ± 0.08^a
	Kidneys (g)	0.64 ± 0.05^a	0.63 ± 0.05^a	0.69 ± 0.06^a	0.68 ± 0.00^a
	Spleen (g)	0.46 ± 0.08^a	0.35 ± 0.01^a	0.46 ± 0.09^a	0.42 ± 0.04^a
	Lung (g)	0.73 ± 0.08^a	0.58 ± 0.03^a	0.64 ± 0.07^a	0.78 ± 0.18^a
	Heart (g)	0.32 ± 0.05^a	0.31 ± 0.02^a	0.31 ± 0.00^a	0.31 ± 0.00^a

Values are presented as mean ± standard deviation of 4 repetitions. In the same line and by sex, the values bearing the different letters are significantly different ().