Acute and Subacute Toxicity Profiles of the Methanol Extract of Lycopersicon esculentum L. Leaves (Tomato), a Botanical with Promising In Vitro Anticancer Potential

Table 4

Biochemical parameters (ALAT and ASAT) in the serum of female and male rats orally treated with methanolic extract of L. esculentum.

Sexes	Parameters	Control	L. Esculentum extract doses (mg/kg)
			250	500	1000
Female	ALAT (U/I)	27.06 ± 4.96^ab	22.26 ± 2.89^a	32.30 ± 5.91^b	22.11 ± 3.51^a
	ASAT (U/I)	38.41 ± 2.78^b	27.06 ± 3.55^a	42.77 ± 5.05^b	30.84 ± 3.77^a
	T. proteins (g/dL)	5.10 ± 0.15^a	5.42 ± 0.33^a	5.09 ± 0.56^a	5.06 ± 0.29^a
Male	ALAT (U/I)	35.39 ± 2.69^b	28.80 ± 1.56^a	28.15 ± 2.62^a	26.62 ± 1.56^a
	ASAT (U/I)	49.85 ± 4.95^b	41.90 ± 3.05^a	38.41 ± 1.96^a	43.21 ± 2.89^a
	T. proteins (g/dL)	3.91 ± 0.09^a	3.88 ± 0.23^a	3.56 ± 0.14^a	4.68 ± 0.16^b

Values are presented as mean ± standard deviation of 4 repetitions. In the same line and by sex, the values bearing the different letters are significantly different (). ALAT: alanine aminotransferase; ASAT: aspartate aminotransaminase; T. proteins: total proteins.