Acute and Subacute Toxicity Profiles of the Methanol Extract of Lycopersicon esculentum L. Leaves (Tomato), a Botanical with Promising In Vitro Anticancer Potential

Table 5

Effect of L. esculentum extraction on the level of serum creatinine and serum urea.

Sexes	Parameters (mg/dL)	Control	L. esculentum extract doses (mg/kg)
			250	500	1000
Female	Creatinine	1.03 ± 0.23^a	0.69 ± 0.17^a	0.86 ± 0.48^a	1.01 ± 0.37^a
	Urea	103.47 ± 3.96^b	70.13 ± 3.96^a	103.24 ± 6.41^b	184.72 ± 3.65^c
Male	Creatinine	0.66 ± 0.11^a	0.88 ± 0.13^a	0.77 ± 0.23^a	0.95 ± 0.16^a
	Urea	70.83 ± 5.21^a	75.00 ± 7.54^a	73.14 ± 6.46^a	138.88 ± 5.88^b

Values are presented as mean ± standard deviation of 4 repetitions. In the same line and by sex, the values bearing the different letters are significantly different ().