Acute and Subacute Toxicity Profiles of the Methanol Extract of Lycopersicon esculentum L. Leaves (Tomato), a Botanical with Promising In Vitro Anticancer Potential

Table 6

Effect of administration of methanolic extract of the leaves of L. esculentum on lipid profile in both female and male rats.

Sexes	Parameters	Control	L. esculentum extract doses (mg/kg)
			250	500	1000
Female	TG (mg/dL)	61.25 ± 3.40^ab	56.84 ± 1.76^a	64.88 ± 2.44^b	58.63 ± 7.23^ab
	TC (mg/dL)	56.37 ± 2.16^a	76.47 ± 2.20^b	60.17 ± 3.63^a	58.16 ± 2.72^a
	HDL (mg/dL)	39.55 ± 2.16^a	55.67 ± 3.55^c	45.33 ± 0.79^b	39.10 ± 2.16^a
	LDL (mg/dL)	4.52 ± 0.81^b	9.42 ± 1.45^d	1.85 ± 0.10^a	7.33 ± 0.94^c
	AI	0.42 ± 0.02^b	0.37 ± 0.05^a	0.32 ± 0.02^a	0.48 ± 0.03^c
Male	TG (mg/dL)	129.56 ± 8.40^c	111.77 ± 3.36^b	110.56 ± 6.24^b	93.45 ± 1.45^a
	TC (mg/dL)	85.66 ± 2.50^b	72.79 ± 3.48^a	76.59 ± 2.50^a	77.08 ± 2.70^a
	HDL(mg/dL)	46.76 ± 2.83^b	44.62 ± 2.05^ab	41.49 ± 2.44^a	45.74 ± 1.60^b
	LDL (mg/dL)	12.98 ± 1.56^b	5.81 ± 0.52^a	12.98 ± 1.47^b	12.64 ± 1.38^b
	AI	0.88 ± 0.04^b	0.63 ± 0.05^a	0.84 ± 0.06^b	0.68 ± 0.07^a

Values are presented as mean ± standard deviation of 4 repetitions. In the same line and by sex, the values bearing the different letters are significantly different (). TG: triglyceride; (TC): total cholesterol; HDL: high-density lipoproteins; AI: atherosclerosis-index.