Evidence-Based Complementary and Alternative Medicine

Research Article

Acute and Subacute Toxicity Profiles of the Methanol Extract of Lycopersicon esculentum L. Leaves (Tomato), a Botanical with Promising In Vitro Anticancer Potential

Table 7

Hematological parameters of female and male rats.


Sexes	Parameters	Control	L. esculentum extract doses (mg/kg)
Sexes	Parameters	Control	250	500	1000

Female	WBCs(X 10³/μl)	14.10 ± 0.60^a	12.23 ± 1.48^a	14.46 ± 1.42^a	13.96 ± 1.45^a
	Lymph (%)	83.50 ± 4.21^b	70.30 ± 4.90^a	76.80 ± 6.87^ab	77.06 ± 6.90^ab
	MONO (%)	7.63 ± 0.94^ab	9.35 ± 1.95^b	5.73 ± 0.60^a	6.60 ± 0.26^a
	PLT (X 10³/μl)	677.33 ± 30.07^d	342.63 ± 38.01^a	592.66 ± 20.03^c	466.66 ± 31.06^b
	MPV (fL)	11.03 ± 1.36^a	10.46 ± 1.50^a	10.56 ± 1.62^a	11.83 ± 1.12^a
	RBCs(X 10⁶/μl)	7.29 ± 0.20^a	7.60 ± 1.14^a	7.73 ± 1.71^a	6.92 ± 0.18^a
	Hb (g/dL)	16.60 ± 0.70^a	15.66 ± 0.15^a	15.26 ± 0.83^a	15.63 ± 0.68^a
	HCT (%)	45.63 ± 3.82^a	45.73 ± 7.07^a	46.20 ± 9.92^a	42.00 ± 1.83^a
	MCV (fL)	62.60 ± 3.98^a	60.20 ± 0.75^a	59.46 ± 1.13^a	60.73 ± 1.49^a
	MCH (pg)	22.70 ± 0.88^a	20.83 ± 2.80^a	20.06 ± 3.52^a	22.56 ± 0.60^a
	MCHC (g/dL)	36.40 ± 1.76^a	34.70 ± 4.87^a	33.76 ± 5.45^a	37.16 ± 0.15^a

Male	WBCs(X 10³/μl)	10.60 ± 1.01^a	15.96 ± 0.64^b	17.86 ± 1.79^bc	19.50 ± 0.80^c
	Lymph (%)	54.96 ± 2.23^a	68.36 ± 2.15^b	70.43 ± 5.70^b	73.66 ± 2.19^b
	MONO (%)	8.36 ± 0.68^a	8.90 ± 0.75^ab	10.06 ± 0 .40^b	9.15 ± 0.45^ab
	PLT (X 10³/μl)	334.33 ± 44.81^a	429.33 ± 35.64^b	397.66 ± 8.73^ab	450.00 ± 34.11^b
	MPV (fL)	9.70 ± 2.26^a	9.56 ± 0.40^a	8.70 ± 0.30^a	9.83 ± 1.55^a
	RBCs(X 10⁶/μl)	6.34 ± 1.93^a	6.91 ± 0.32^a	6.71 ± 1.03^a	7.86 ± 0.58^a
	Hb (g/dL)	15.43 ± 1.41^a	15.46 ± 0.66^a	13.80 ± 3.40^a	17.06 ± 1.01^a
	HCT (%)	39.20 ± 7.07^a	39.00 ± 2.95^a	39.76 ± 7.15^a	44.66 ± 3.66^a
	MCV (fL)	63.90 ± 10.23^a	56.43 ± 3.36^a	59.16 ± 2.56^a	56.83 ± 0.80^a
	MCH (pg)	25.66 ± 6.79^a	22.30 ± 1.12^a	20.43 ± 3.37^a	21.70 ± 0.75^a
	MCHC (g/dL)	39.80 ± 4.01^a	39.66 ± 1.50^a	34.53 ± 4.28^a	38.20 ± 1.30^a

Values are presented as mean ± standard deviation of 4 repetitions. In the same line and by sex, the values bearing the different letters are significantly different (). WBCs: white blood cells, Lymph: lymphocytes, Mono: monocytes, PLT: platelets, MPV: mean platelet volume, RBCs: red blood cells, Hb: hemoglobin, HCT: hematocrit, MCV: mean corpuscular volume, MCH: mean corpuscular hemoglobin, MCHC: mean corpuscular hemoglobin concentration.