Sesamin Promotes Neurite Outgrowth under Insufficient Nerve Growth Factor Condition in PC12 Cells through ERK1/2 Pathway and SIRT1 Modulation

<div>Effect of sesamin and nerve growth factor (NGF) on PC12 cell viability. (a) Structure of sesamin. (b) To study the effect of sesamin or NGF on cell viability, PC12 cells were seeded at 1 × 10<sup>4</sup> cells/well in 96-well plate. Then, cells were treated with sesamin alone at 1, 5, and 10 <i>μ</i>M or with NGF at 20 and 40 ng/ml. To investigate the cytotoxic effect of combination treatment between sesamin and NGF, cells were cotreated with sesamin (1, 5, and 10 <i>μ</i>M) and NGF (20 or 40 ng/ml). After 24 h incubation, PC12cell viability was measured by MTT assay. Data represent the means ± SD of three independent experiments.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 1: Sesamin Promotes Neurite Outgrowth under Insufficient Nerve Growth Factor Condition in PC12 Cells through ERK1/2 Pathway and SIRT1 Modulation 

Figure 1 | Sesamin Promotes Neurite Outgrowth under Insufficient Nerve Growth Factor Condition in PC12 Cells through ERK1/2 Pathway and SIRT1 Modulation 