Adlay Seed (Coix lacryma-jobi L.) Extracts Exhibit a Prophylactic Effect on Diet-Induced Metabolic Dysfunction and Nonalcoholic Fatty Liver Disease in Mice

Figure 1

Effect of ASE and ASW on glucose metabolism, glucose tolerance, and insulin resistance in C57BL/6J mice fed by HFD. (a) The experimental approach. Six-week-old male C57BL/6 mice were divided into four groups and fed normal diet (ND), high-fat diet (HFD), 1% ASE mixed with HFD, and 3% ASW mixed with HFD for 10 weeks. At 16 weeks of age, the follow-up analysis was conducted. (b) Blood glucose levels after 16 h of fasting. (c) Curve of normalized IPGTT. Data are normalized by subtracting the baseline value (fasting blood glucose) from the measured value in each mouse. (d) Area under the curve (AUC) of blood glucose in the IPGTT assay. (e) Serum insulin levels after 16 h of fasting. (f) The HOMA-IR index calculated using fasting blood glucose and insulin levels. Data are shown as means ± SEM (n = 6 in each group). HFD vs. ND, ASE, or ASW, in increased level. HFD vs. ND, ASE, or ASW, ; , in decreased level.

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