Jisuikang Promotes the Repair of Spinal Cord Injury in Rats by Regulating NgR/RhoA/ROCK Signal Pathway

Figure 2

JSK improved the microstructure of neurons in rats with SCI. In the sham group, the shape of spinal myelin sheath was regular, like concentric circular arrangement, and it had a complete structure. The neurons were oval and had complete cell membrane structure, abundant organelles, more mitochondria and rough endoplasmic reticulum, no obvious rupture, or deletion of mitochondrial crest, and the morphology at 7 d–28 d was basically the same. In the model group, the shape of spinal myelin sheath was irregular, and the structure was disordered and incomplete, with partial breakage or deletion, local curl, and wrinkle. The number of neurons and mitochondria decreased, and there were dissolution of part of mitochondria, rupture and deletion of mitochondrial crest, and little change in morphology on 7 d–28 d. The myelin sheath shape of the spinal cord in the JSK group and the prednisone group was improved, the shape was more regular, the structure was more complete, the number of neurons and mitochondria was more, and the morphology of 7 d–28 d was greatly improved compared with the model group. Note. The red arrow indicates the myelin sheath and the green arrow indicates the mitochondria.