Jisuikang Promotes the Repair of Spinal Cord Injury in Rats by Regulating NgR/RhoA/ROCK Signal Pathway

Figure 3

JSK improved the dendritic morphology of neurons in rats with SCI. (a) In the sham group, the morphology of spinal cord dendrites was regular, complete, and long, the dendritic spines arranged neatly, compact, and numerous, and the morphology at 7 d–28 d was basically the same. In the model group, the morphology of spinal cord dendrites was irregular, partially missing, and short, and the arrangement of dendritic spines was disordered and sparse, the number was less, and the morphological changes of 7 d–28 d were not much. In prednisone group and JSK group, the morphology of the spinal cord dendrites was improved, the shape was more regular, the structure was more complete, the length was longer, the dendritic spines were arranged neatly, the density was more uniform, the number was more, and the morphology of 7 d–28 d gradually improved. ((b), (c)) The length of dendrites and the number of dendritic spines in each group were statistically analyzed. The length of dendrites in the sham group was the longest and the number of dendritic spines was the most, while that in the model group was the shortest and the number of dendritic spines was the fewest. Compared with the sham group, the dendritic length and the number of dendritic spines in the model group were significantly decreased, and the dendritic length and the number of dendritic spines in the JSK group were significantly increased compared with the model group. Note. The red arrow indicates the dendritic spine, and the data were presented as mean ± SD; n = 3/group, , and .

(a)

(b)

(c)