Jisuikang Promotes the Repair of Spinal Cord Injury in Rats by Regulating NgR/RhoA/ROCK Signal Pathway

Figure 6

JSK could reduce the expression of NgR in the injured area of rats with SCI. (a) Representative images of immunohistochemistry. (b) Immunohistochemical statistics showed that, on the 28th day, the expression of NgR in the injured area of spinal cord increased but decreased after intervention of JSK. Compared with the sham group, the expression of NgR in the model group was significantly increased, and compared with the model group, JSK could significantly reduce the expression of NgR. (c) Representative images of western blot result. ((d), (e), (f), (g), (h), and (i)) The statistical results of western blot and qRT-PCR showed that, on the 28th day, the expression of NgR/RhoA/ROCK in the injured area of spinal cord increased but decreased after intervention of JSK. Compared with the sham group, the expression of NgR/RhoA/ROCK in the model group was significantly increased, and compared with the model group, JSK could significantly reduce the expression of NgR/RhoA/ROCK. NOTE: a is the model group, b is the prednisone group, c is the prednisone group, and d is the sham group. The data were presented as mean ± SD; n = 3/group, , and .

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)