Effect of You-Gui Yin on the Activities of Seven Cytochrome P450 Isozymes in Rats

Figure 1

UPLC-MS/MS chromatograms of probes and the internal standard in SD rat plasma. (a) Blank plasma; (b) blank plasma with mixed probe substrates and glibenclamide (IS); (c) plasma sample obtained from a rat after intravenous injection of the cocktail probe drugs spiked with the IS; (1) phenacetin; (2) bupropion; (3) amodiaquine; (4) diclofenac; (5) omeprazole; (6) dextromethorphan; (7) midazolam; and (8) glibenclamide.

(a)

(b)