Effect of You-Gui Yin on the Activities of Seven Cytochrome P450 Isozymes in Rats

Table 2

Interday and intraday precision of seven probe drugs in rat plasma.

	Add (ng/mL)	Interday precision		Intraday precision
		Mean ± SD (ng/mL)	RSD (%)	Mean ± SD (ng/mL)	RSD (%)
Phenacetin	20	20.43 ± 1.72	8.44	19.91 ± 1.20	6.03
	50	52.19 ± 0.93	1.78	49.61 ± 2.02	4.07
	1200	1208.04 ± 40.04	3.31	1220.00 ± 5.32	0.43
Bupropion	0.5	0.50 ± 0.05	11.57	0.52 ± 0.03	7.66
	25	24.67 ± 0.32	1.30	25.31 ± 0.61	2.42
	320	324.07 ± 12.12	3.74	321.83 ± 3.44	1.06
Diclofenac	40	39.21 ± 0.73	1.86	39.38 ± 1.06	2.71
	1000	1025.65 ± 16.92	1.65	1010.52 ± 19.73	1.95
	5120	4933.36 ± 100.09	2.02	5110.28 ± 40.97	0.80
Amodiaquine\	0.5	0.52 ± 0.02	4.69	0.52 ± 0.03	7.28
	10	9.72 ± 0.51	5.31	10.82 ± 0.37	3.46
	40	39.35 ± 2.04	5.20	42.77 ± 1.23	2.88
Omeprazole	4	3.84 ± 0.47	12.30	4.06 ± 0.18	4.61
	100	101.09 ± 4.28	4.23	97.78 ± 1.44	1.47
	600	595.17 ± 11.55	1.94	606.19 ± 18.86	3.11
Dextromethorphan	1	0.98 ± 0.08	8.49	0.53 ± 0.04	8.44
	20	20.51 ± 0.59	2.89	21.00 ± 0.40	1.91
	120	118.30 ± 3.15	2.66	122.14 ± 1.17	0.90
Midazolam	2	1.97 ± 0.15	8.01	2.00 ± 0.12	6.35
	50	51.10 ± 0.24	0.47	50.44 ± 0.67	0.13
	512	514.25 ± 15.24	2.96	514.92 ± 12.00	2.33