Effect of You-Gui Yin on the Activities of Seven Cytochrome P450 Isozymes in Rats

Table 3

Pharmacokinetic parameters of probe substrates in rats (n = 6).

CYPs	Parameters	CG	LG	MG	HG
CYP1A2	AUC(0–t) (μg/mL  min)	23.76 ± 4.14	12.69 ± 3.64	23.71 ± 3.82	21.62 ± 4.24
	AUC(0–∞) (μg/mL  min)	26.11 ± 3.05	13.37 ± 3.83	26.60 ± 4.75	54.19 ± 28.36
	Cmax (μg/L)	731.71 ± 130.08	651.93 ± 194.76	666.06 ± 150.93	582.09 ± 131.24
	T1/2 (min)	131.08 ± 51.17	141.84 ± 58.28	123.57 ± 117.91	120.15 ± 81.23
	CL (L/min/kg)	0.039 ± 0.004	0.04 ± 0.02	0.039 ± 0.007	0.02 ± 0.01
CYP2B6	AUC(0–t) (μg/mL  min)	15.06 ± 4.18	12.88 ± 4.02	14.87 ± 1.53	12.79 ± 3.27
	AUC(0–∞) (μg/mL  min)	16.18 ± 4.00	13.40 ± 4.25	16.69 ± 1.59	13.30 ± 3.45
	Cmax (μg/L)	184.38 ± 52.69	239.23 ± 60.79	190.86 ± 34.25	218.76 ± 41.79
	T1/2 (min)	97.57 ± 49.83	75.77 ± 14.62	116.10 ± 32.76	81.97 ± 10.06
	CL (L/min/kg)	0.06 ± 0.01	1.64 ± 0.60	0.06 ± 0.006	0.08 ± 0.02
CYP2C8	AUC(0–t) (ug/mL∗min)	0.31 ± 0.07	0.27 ± 0.09	0.33 ± 0.10	0.24 ± 0.09
	AUC(0–∞) (ug/mL∗min)	0.34 ± 0.08	0.37 ± 0.17	0.41 ± 0.10	0.35 ± 0.20
	Cmax (μg/L)	25.16 ± 7.53	23.52 ± 6.26	19.51 ± 3.20	15.92 ± 6.05
	T1/2 (min)	142.06 ± 54.05	252.85 ± 86.51	226.42 ± 93.44	260.97 ± 187.48
	CL (L/min/kg)	0.30 ± 0.10	0.31 ± 0.13	0.25 ± 0.07	0.37 ± 0.22

YGY groups were compared with the control group; ; .