Research Article
Effect of You-Gui Yin on the Activities of Seven Cytochrome P450 Isozymes in Rats
Table 4
Pharmacokinetic parameters of probe substrates in rats (n = 6).
| CYPs | Parameters | CG | LG | MG | HG |
| CYP2C9 | AUC(0–t) (μg/mL min) | 88.15 ± 16.98 | 73.49 ± 22.70 | 52.89 ± 17.98 | 43.77 ± 10.14 | AUC(0–∞) (μg/mL min) | 98.47 ± 33.79 | 76.70.±24.57 | 55.30 ± 16.80 | 46.47 ± 12.30 | Cmax (μg/L) | 3249.80 ± 477.10 | 2886.50 ± 910.14 | 2168.10 ± 580.76 | 1704.55 ± 469.94 | T1/2 (min) | 44.82 ± 32.28 | 33.26 ± 17.47 | 41.09 ± 13.74 | 66.95 ± 32.50 | CL (L/min/kg) | 0.011 ± 0.004 | 0.015 ± 0.006 | 0.020 ± 0.006 | 0.023 ± 0.006 |
| CYP2C19 | AUC(0–t) (μg/mL min) | 11.69 ± 4.26 | 9.33 ± 2.43 | 8.02 ± 1.90 | 5.81 ± 1.66 | AUC(0–∞) (μg/mL min) | 12.00 ± 4.50 | 9.37 ± 2.49 | 8.30 ± 1.82 | 6.29 ± 1.98 | Cmax (μg/L) | 386.85 ± 100.73 | 392.31 ± 99.73 | 187.68 ± 52.60 | 219.93 ± 40.77 | T1/2 (min) | 46.88 ± 19.39 | 29.19 ± 9.09 | 52.10 ± 20.39 | 79.74 ± 61.35 | CL (L/min/kg) | 0.09 ± 0.02 | 0.11 ± 0.03 | 0.12 ± 0.02 | 0.17 ± 0.04 |
| CYP2D6 | AUC(0–t) (μg/mL min) | 13.64 ± 3.38 | 14.13 ± 7.42 | 14.96 ± 2.92 | 13.58 ± 3.20 | AUC(0–∞) (μg/mL min) | 14.97 ± 3.34 | 15.09 ± 7.33 | 15.32 ± 3.01 | 14.91 ± 3.23 | Cmax (ug/L) | 116.17 ± 50.04 | 156.60 ± 98.86 | 73.13 ± 13.31 | 98.33 ± 30.40 | T1/2 (min) | 99.92 ± 36.30 | 95.19 ± 25.69 | 98.49 ± 40.09 | 99.92 ± 36.30 | CL (L/min/kg) | 1.40 ± 0.37 | 1.55 ± 0.63 | 1.52 ± 0.31 | 1.40 ± 0.37 |
| CYP3A4 | AUC(0–t) (μg/mL min) | 16.09 ± 3.54 | 13.31 ± 4.17 | 12.19 ± 2.46 | 8.33 ± 2.30 | AUC(0–∞) (μg/mL min) | 19.78 ± 7.30 | 13.98 ± 4.78 | 14.16 ± 4.72 | 9.38 ± 2.82 | Cmax (μg/L) | 414.02 ± 71.52 | 407.09 ± 121.13 | 301.84 ± 41.80 | 267.62 ± 57.04 | T1/2 (min) | 48.05 ± 33.65 | 25.75 ± 8.94 | 40.12 ± 20.57 | 36.02 ± 23.21 | CL (L/min/kg) | 1.12 ± 0.38 | 1.62 ± 0.72 | 1.52 ± 0.42 | 2.28 ± 0.62 |
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YGY groups were compared with the control group; ; . |