Research Article

Effect of You-Gui Yin on the Activities of Seven Cytochrome P450 Isozymes in Rats

Table 4

Pharmacokinetic parameters of probe substrates in rats (n = 6).

CYPsParametersCGLGMGHG

CYP2C9AUC(0–t) (μg/mL  min)88.15 ± 16.9873.49 ± 22.7052.89 ± 17.9843.77 ± 10.14
AUC(0–∞) (μg/mL  min)98.47 ± 33.7976.70.±24.5755.30 ± 16.8046.47 ± 12.30
Cmax (μg/L)3249.80 ± 477.102886.50 ± 910.142168.10 ± 580.761704.55 ± 469.94
T1/2 (min)44.82 ± 32.2833.26 ± 17.4741.09 ± 13.7466.95 ± 32.50
CL (L/min/kg)0.011 ± 0.0040.015 ± 0.0060.020 ± 0.0060.023 ± 0.006

CYP2C19AUC(0–t) (μg/mL  min)11.69 ± 4.269.33 ± 2.438.02 ± 1.905.81 ± 1.66
AUC(0–∞) (μg/mL  min)12.00 ± 4.509.37 ± 2.498.30 ± 1.826.29 ± 1.98
Cmax (μg/L)386.85 ± 100.73392.31 ± 99.73187.68 ± 52.60219.93 ± 40.77
T1/2 (min)46.88 ± 19.3929.19 ± 9.0952.10 ± 20.3979.74 ± 61.35
CL (L/min/kg)0.09 ± 0.020.11 ± 0.030.12 ± 0.020.17 ± 0.04

CYP2D6AUC(0–t) (μg/mL  min)13.64 ± 3.3814.13 ± 7.4214.96 ± 2.9213.58 ± 3.20
AUC(0–∞) (μg/mL  min)14.97 ± 3.3415.09 ± 7.3315.32 ± 3.0114.91 ± 3.23
Cmax (ug/L)116.17 ± 50.04156.60 ± 98.8673.13 ± 13.3198.33 ± 30.40
T1/2 (min)99.92 ± 36.3095.19 ± 25.6998.49 ± 40.0999.92 ± 36.30
CL (L/min/kg)1.40 ± 0.371.55 ± 0.631.52 ± 0.311.40 ± 0.37

CYP3A4AUC(0–t) (μg/mL  min)16.09 ± 3.5413.31 ± 4.1712.19 ± 2.468.33 ± 2.30
AUC(0–∞) (μg/mL  min)19.78 ± 7.3013.98 ± 4.7814.16 ± 4.729.38 ± 2.82
Cmax (μg/L)414.02 ± 71.52407.09 ± 121.13301.84 ± 41.80267.62 ± 57.04
T1/2 (min)48.05 ± 33.6525.75 ± 8.9440.12 ± 20.5736.02 ± 23.21
CL (L/min/kg)1.12 ± 0.381.62 ± 0.721.52 ± 0.422.28 ± 0.62

YGY groups were compared with the control group; ; .