Electroacupuncture Pretreatment as a Novel Avenue to Protect Heart against Ischemia and Reperfusion Injury

Table 1

Summary of effect evaluation parameters of EA pretreatment against MIRI in animal experiments.

Reference	Species	Models	Infarct reduction	Effect evaluation parameters
Gao et al. [22]	Rats	30 min LADCA ligation, 15 min reperfusion	∼44%	ST segment of ECG; cardiac arrhythmias; risk zone/infarct size
Huang et al. [24]	Rats	30 min LADCA ligation, 240 min reperfusion	∼55%	Arrhythmic; infarct size and myocardial enzymes; gene expressions genome-widely
Gao et al. [28]	Rats	40 min isolated heart reduced-flow perfusion, 10 min reperfusion	No morphological study	Arrhythmia; [Ca^2+]i in resting single ventricular myocyte; Cx43 protein levels in ventricular myocytes; nonphosphorylated Cx43 in ventricular myocytes
Shao et al. [29]	Rats	30 min LADCA ligation, 30 min reperfusion	No morphological study	ST segment displacement value; SOD, MDA content in serum; cardiomyocyte tissue structure; ultramicrostructure of cardiomyocytes; expression of Nrf2 and HO-1 genes in myocardial tissue
Wang et al. [30]	Rabbits	40 min LADCA ligation, 60 min reperfusion	No morphological study	NO, NOS content in serum; adenosine content in serum