Review Article

Electroacupuncture Pretreatment as a Novel Avenue to Protect Heart against Ischemia and Reperfusion Injury

Table 1

Summary of effect evaluation parameters of EA pretreatment against MIRI in animal experiments.

ReferenceSpeciesModelsInfarct reductionEffect evaluation parameters

Gao et al. [22]Rats30 min LADCA ligation, 15 min reperfusion∼44%ST segment of ECG; cardiac arrhythmias; risk zone/infarct size
Huang et al. [24]Rats30 min LADCA ligation, 240 min reperfusion∼55%Arrhythmic; infarct size and myocardial enzymes; gene expressions genome-widely
Gao et al. [28]Rats40 min isolated heart reduced-flow perfusion, 10 min reperfusionNo morphological studyArrhythmia; [Ca2+]i in resting single ventricular myocyte; Cx43 protein levels in ventricular myocytes; nonphosphorylated Cx43 in ventricular myocytes
Shao et al. [29]Rats30 min LADCA ligation, 30 min reperfusionNo morphological studyST segment displacement value; SOD, MDA content in serum; cardiomyocyte tissue structure; ultramicrostructure of cardiomyocytes; expression of Nrf2 and HO-1 genes in myocardial tissue
Wang et al. [30]Rabbits40 min LADCA ligation, 60 min reperfusionNo morphological studyNO, NOS content in serum; adenosine content in serum