Research Article
Analysis of the Molecular Mechanisms of the Effects of Prunella vulgaris against Subacute Thyroiditis Based on Network Pharmacology
Table 3
The topological parameters of the C-T-P network.
| | Number | Node | Degree centrality (DC) | Betweenness centrality (BC) |
| | 1 | Quercetin | 29 | 0.28053366 | | 2 | Luteolin | 18 | 0.09443417 | | 3 | Kaempferol | 16 | 0.07144764 | | 4 | Beta-sitosterol | 12 | 0.05629246 | | 5 | Stigmasterol | 8 | 0.02265721 | | 6 | Morin | 7 | 0.01050266 | | 7 | Delphinidin | 6 | 0.00842733 | | 8 | Vulgaxanthin-I | 2 | 1.68E − 04 | | 9 | Spinasterol | 1 | 0 | | 10 | Poriferasterol monoglucoside_qt | 1 | 0 | | 11 | Stigmast-7-enol | 1 | 0 | | 12 | PIK3CG | 19 | 0.101838 | | 13 | MAPK1 | 17 | 0.066987 | | 14 | MAPK14 | 16 | 0.068118 | | 15 | TNF | 12 | 0.039517 | | 16 | PTGS2 | 11 | 0.044665 | | 17 | ESR1 | 11 | 0.107751 | | 18 | JUN | 10 | 0.025135 | | 19 | NOS2 | 10 | 0.039108 | | 20 | MAPK8 | 9 | 0.016002 | | 21 | EGFR | 9 | 0.025645 | | 22 | GSK3B | 9 | 0.019636 | | 23 | CDK2 | 9 | 0.025971 | | 24 | BCL2 | 8 | 0.019616 | | 25 | NOS3 | 8 | 0.022166 | | 26 | TP53 | 8 | 0.021252 | | 27 | IL6 | 7 | 0.010758 | | 28 | VEGFA | 7 | 0.009984 | | 29 | EGF | 6 | 0.007181 | | 30 | IFNG | 5 | 0.005949 | | 31 | VCAM1 | 4 | 0.003979 | | 32 | CDK4 | 4 | 0.004304 | | 33 | IL2 | 4 | 0.002602 | | 34 | MET | 4 | 0.002161 | | 35 | CHEK1 | 4 | 0.006204 | | 36 | HTR2A | 4 | 0.004661 | | 37 | CCL2 | 3 | 0.001973 | | 38 | SELE | 3 | 0.001084 | | 39 | MMP2 | 3 | 0.002267 | | 40 | CDK1 | 3 | 0.003758 | | 41 | PLAU | 3 | 0.00391 | | 42 | ADRA1A | 3 | 0.001579 | | 43 | MMP3 | 2 | 4.95E − 04 | | 44 | CTSD | 2 | 6.58E − 04 | | 45 | PTGER3 | 2 | 0.002331 | | 46 | PI3K-Akt signaling pathway | 14 | 0.042792 | | 47 | TNF signaling pathway | 12 | 0.0336 | | 48 | HIF-1 signaling pathway | 10 | 0.018361 | | 49 | T Cell receptor signaling pathway | 9 | 0.015969 | | 50 | Sphingolipid signaling pathway | 9 | 0.018039 | | 51 | MAPK signaling pathway | 8 | 0.010468 | | 52 | Toll-like receptor signaling pathway | 7 | 0.005861 | | 53 | Rap1 signaling pathway | 7 | 0.008431 | | 54 | Ras signaling pathway | 7 | 0.009325 | | 55 | NOD-like receptor signaling pathway | 6 | 0.005763 | | 56 | VEGF signaling pathway | 6 | 0.005997 | | 57 | GnRH signaling pathway | 6 | 0.006022 | | 58 | Calcium signaling pathway | 6 | 0.012494 | | 59 | p53 signaling pathway | 5 | 0.004671 | | 60 | NF-kappa B signaling pathway | 5 | 0.004721 | | 61 | Thyroid hormone signaling pathway | 5 | 0.007399 | | 62 | Apoptosis | 4 | 0.002136 | | 63 | B-cell receptor signaling pathway | 4 | 0.001427 | | 64 | Natural killer cell mediated cytotoxicity | 4 | 0.002105 | | 65 | Inflammatory mediator regulation of TRP channels | 4 | 0.006817 |
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