| | Component | Degree | Target gene |
| | Catalpol | 1 | LGALS3 | | Aucubin | 1 | LGALS3 | | Gallic acid | 27 | CA1, TTR, IGF1R, SERPINE1, COMT, ALB, KDR, CNR2, ESR1, PARP1, FASN, ELANE, ADRA2A, ADRA2C, ADRA2B、ADRB2、DRD3、PTPN1、PTGS2, EGFR, DPP4, CNR1, FTO, OPRM1, PTGS1, RXRG, RXRA | | Rhmannioside D | 17 | CA1, FGF2, HRAS, FN1, F2, F7, SIRT1, AKR1B1, PTPN1, SLC5A2, ACE, SELP, MMP2, MMP12, STAT3, PRKCD, RORC | | Leonuride | 1 | SLCO1B3 | | Hydroxysafflor yellow A | 24 | CA1, PTPN1, SLC6A4, PTGS2, PRKCD, TERT, IKBKB, GSTM1, ACP1, PTPN2, GSK3B, AKR1B1, ABCB1, MMP2, MMP12, HSD11B1, APP, CNR1, MTOR, HMGCR, TLR9, F2, F10, IL1B | | Amygdalin | 1 | LGALS3 | | Echinacoside | 2 | ALDH2, LGALS3 | | Calycosin-7-O-β-D-glucoside | 31 | TNF, ALDH2, AKR1B1, CA1, XDH, HRAS, MAPK14, F10, ADRA2C, PARP1, ABCB1, HCAR2, PTGS1, ADRA2A, EGFR, CD38, MIF, MMP9, MMP2, MMP8, ALB, MMP12, PTPN22, TLR9, PPARA, APP、LGALS3, IRAK4, SLC5A2, CASP1, INSR | | Ononin | 3 | ALDH2, MTTP, SHBG | | Calycosin | 27 | ABCB1, MIF, PPARA, ESR1, TLR9, EGFR, PTGS1, ALDH2, XDH, CA1, PTPN1, PON1, PLAT, F10, TNF, IGFBP3, AKR1B1, SNCA, GCGR, ADRB2, KDM1A, TNNC1, TNNT2, TNNI3, IGFBP5, IGFBP2, IGFBP1, PPARG, ALOX5 | | Astragaloside IV | 31 | VEGFA, FGF1, FGF2, HPSE, LGALS3, ADRA2A, ABCB1, ADRA2C, ADRA2B, STAT3, AKT2, AKT1, CNR1, CNR2, FAAH, ADRB2, MTOR, PIK3CG, RORC, F10, IGF2R, DRD3、F7, VDR, PIK3CA, PIK3R1, PTPN2, EGFR, MMP1, SLC6A4, SELL, SELP | | Astragaloside III | 26 | VEGFA, FGF1, FGF2, HPSE, LGALS3, RORC, ADRA2A, ADRA2C, ADRA2B, DRD3、STAT3、VDR, SLC5A1, CNR1, CNR2、HSD11B2、HSD11B1, ABCB1, ADRB2, MMP2, MMP12, IGF2R, GLB1, PPARG, ADRB3, IGF1R | | Ophiopojaponin C | 28 | STAT3, F2, HSD11B2, HSD11B1, PTPN1, ADRB2, MMP2, MMP8, SLC5A2, SLC5A1, AKR1B1, ADRA2A, ADRA2C, ADRA2B, OPRM1, IGF1R, CASP1, DGAT1, EPHX2, LIPC, KCNH2, PRKCD, NR3C1, MMP1, FAAH, ABCG2, DPP4, ADRB3 | | Astragaloside II | 31 | VEGFA, FGF1, FGF2, HPSE, ABCB1, ADRA2A, ADRA2C, ADRA2B, STAT3, LGALS3, VDR, RORC, REN, IKBKB, ADRB2, SLC5A1, CNR1, CNR2, DRD3, EGFR, FAAH, IGF1R, IGF2R, AKT2, AKT1, INSR, FKBP5, LIPC, MMP1, TLR9, MTOR | | Formononetin | 4 | ESR1, MTTP, AKT1, SHBG | | Isoastragaloside II | 32 | VEGFA, FGF1, FGF2, HPSE, ABCB1, ADRA2A, ADRA2C, ADRA2B, STAT3, LGALS3, VDR, RORC, REN, IKBKB, ADRB2, SLC5A1, CNR1, CNR2, DRD3, EGFR, FAAH, IGF1R, IGF2R, AKT2, AKT1, INSR, FKBP5, LIPC, MMP1, TLR9, MTOR, SLCO1B3 | | Rhein | 11 | ALOX5, MAPK8IP1, CYP1A2, CYP2C9, CYP3A4, CYP3A43, CYP3A5, GSTP1, NR1H2, PTGS1, PTGS2 | | Astragaloside I | 27 | VEGFA, FGF1, FGF2, RORC, ADRA2A, ADRA2C, ADRA2B, VDR, LGALS3, MTOR, HPSE, MAPK14, HLA-A, P2RY12, SLC5A1, REN, ABCB1, DRD3, LIPC, MMP9, MMP8, IKBKB, PPARG, F3, F7, CTSD, MMP3, MMP1 | | Isoastragaloside I | 28 | VEGFA, FGF1, FGF2, HPSE, ADRA2C, ADRA2B, ABCB1, VDR, LGALS3, DRD3, RORC, ADRA2A, CNR1, CNR2, SLC5A1, HLA-A, LIPC, TERT, ALDH2, PRKCD, EDNRB, IGF1R, DPP4, REN, MTOR, MMP9, MMP8, AKT1 | | Emodin | 8 | ALOX5, CYP1A2, CYP2C9, CYP3A4, CYP3A43, CYP3A5, GSTP1, NR1H2 |
|
|
