| | Comparative measures | Direct comparison | Indirect comparison | Network meta-analysis | | MD (95% CI) | Quality of evidence | MD (95% CI) | Quality of evidence | MD (95% CI) | Quality of evidence |
| | A VS C | 1.47 (0.92, 2.02) | Moderate% | Not evaluated$ | Not evaluated$ | 1.47 (0.99, 1.95) | Moderate | | H VS C | — | — | 2.67 (1.13, 4.21) | Very low&#! | 2.67 (1.13, 4.21) | Very low | | AT VS C | 3.05 (−0.43, 6.53) | Very low&%! | 2.52 (1.65, 3.38) | Very low##! | 2.55 (1.71, 3.39) | Very low | | AH VS C | 5.45 (1.93, 8.97) | Very low&%! | 6.10 (4.41, 7.79) | Very low#∗! | 5.98 (4.46, 7.50) | Very low | | AU VS C | — | — | 5.82 (4.36, 7.28) | Low#% | 5.82 (4.36, 7.28) | Low | | AR VS C | 3.62 (3.14, 4.10) | Low%! | Not evaluated$ | Not evaluated$ | 3.62 (3.22, 4.02) | Low | | H VS A | 1.11 (−0.47, 2.69) | Low&! | 1.80 (−2.31, 5.91) | Low&! | 1.20 (−0.28, 2.68) | Low | | AT VS A | 1.06 (0.34, 1.78) | Moderate! | 1.59 (−1.92, 5.10) | Very low&#! | 1.08 (0.38, 1.78) | Moderate | | AH VS A | 4.81 (3.11, 6.51) | Very low&%! | 3.60 (0.60, 6.60) | Very low&∗! | 4.51 (3.04, 5.98) | Very low | | AU VS A | 4.35 (2.97, 5.73) | Moderate! | Not evaluated$ | Not evaluated$ | 4.35 (2.97, 5.73) | Moderate | | AR VS A | 2.15 (1.60, 2.70) | Low%! | Not evaluated$ | Not evaluated$ | 2.15 (1.67, 2.63) | Low | | AT VS H | — | — | −0.12 (−1.76, 1.52) | Very low&#! | −0.12 (−1.76, 1.52) | Very low | | AH VS H | 3.36 (1.96, 4.76) | Moderate% | Not evaluated$ | Not evaluated$ | 3.31 (1.94, 4.68) | Moderate | | AU VS H | — | — | 3.15 (1.13, 5.17) | Very low&#! | 3.15 (1.13, 5.17) | Very low | | AR VS H | — | — | 0.95 (−0.59, 2.50) | Very low&#! | 0.95 (−0.59, 2.50) | Very low | | AH VS AT | — | — | 3.43 (1.80, 5.06) | Low&! | 3.43 (1.80, 5.06) | Low | | AU VS AT | — | — | 3.27 (1.72, 4.82) | Very low&!∗ | 3.27 (1.72, 4.82) | Very low | | AR VS AT | — | — | 1.07 (0.23, 1.92) | Very low&!∗ | 1.07 (0.23, 1.92) | Very low | | AU VS AH | — | — | −0.16 (−2.17, 1.86) | Very low&!% | −0.16 (−2.17, 1.86) | Very low | | AR VS AH | — | — | −2.36 (−3.89, −0.83) | Very low&!% | −2.36 (−3.89, −0.83) | Very low | | AR VS AU | — | — | −2.20 (−3.66, −0.74) | Very low&%! | −2.20 (−3.66, −0.74) | Very low |
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&, study limitations; #, indirectness; ∗, inconsistency; %, imprecision; !, publication bias; $, not evaluated, because the treatment protocol is not in the evidence network: indirectness due to nontransitivity or indirectness between the mesh meta-analysis population and the included trial population.
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