System Pharmacology-Based Strategy to Decode the Synergistic Mechanism of GanDouLing for Wilson’s Disease

Table 1

The details of genes wih the node degree > 70.

Gene name	Node degree	Gene description
INS	160	Insulin
ALB	152	Albumin
AKT1	152	AKT serine/threonine kinase 1
IL6	150	Interleukin 6
TP53	128	Tumor protein p53
TNF	125	Tumor necrosis factor
EGFR	111	Epidermal growth factor receptor
EGF	100	Epidermal growth factor
ESR1	100	Estrogen receptor 1
STAT3	98	Signal transducer and activator of transcription 3
IL1B	94	Interleukin 1 beta
IGF1	92	Insulin-like growth factor 1
PTGS2	92	Prostaglandin-endoperoxide synthase 2
CCL2	90	C–C motif chemokine ligand 2
IL10	88	Interleukin 10
PPARG	87	Peroxisome proliferator-activated receptor gamma
NOS3	86	Nitric oxide synthase 3
FOS	86	Fos proto-oncogene, AP-1 transcription factor subunit
CAT	82	Catalase
FGF2	82	Fibroblast growth factor 2
LEP	77	Leptin
EDN1	77	Endothelin 1
MAPK14	75	Mitogen-activated protein kinase 14
PTEN	75	Phosphatase and tensin homolog
SIRT1	73	Sirtuin 1
BDNF	72	Brain derived neurotrophic factor
AGT	71	Angiotensinogen
CRP	71	C-reactive protein
AR	71	Androgen receptor