Evidence-Based Complementary and Alternative Medicine

Review Article

Processing and Compatibility of Corydalis yanhusuo: Phytochemistry, Pharmacology, Pharmacokinetics, and Safety

Table 1

Quantitative changes on the content of Corydalis yanhusuo compounds under different processing methods.


Number	Compounds	Processing method	Processing content (mg/g)	Reference

1	Protopine	None	0.216	[12]
		Stir-baking with vinegar	0.249↑
		Stir-baking with rice wine	0.241↑
2	α-allocryptopine	None	0.559	[12]
		Stir-baking with vinegar	0.644↑
		Stir-baking with rice wine	0.585↑
3	Tetrahydrocolumbamine	None	1.340	[12]
		Stir-baking with vinegar	1.479↑
		Stir-baking with rice wine	1.379↑
4	Coptisine	None	0.290	[12]
		Stir-baking with vinegar	0.300↑
		Stir-baking with rice wine	0.281↓
5	Palmatine	None	0.180	[12]
		Stir-baking with vinegar	0.177↓
		Stir-baking with rice wine	0.204↑
6	Berberine	None	0.084	[12]
		Stir-baking with vinegar	0.078↓
		Stir-baking with rice wine	0.092↑
7	Dehydrocorydaline	None	0.800	[12]
		Stir-baking with vinegar	0.797↓
		Stir-baking with rice wine	0.851↑
8	D, L-tetrahydropalmatine	None	0.321	[12]
		Stir-baking with vinegar	0.339↑
		Stir-baking with rice wine	0.381↑
9	Tetrahydroberberine	None	0.032	[12]
		Stir-baking with vinegar	0.040↑
		Stir-baking with rice wine	0.036↑
10	Corydaline	None	0.189	[12]
		Stir-baking with vinegar	0.224↑
		Stir-baking with rice wine	0.233↑
11	Tetrahydrocoptisine	None	0.033	[12]
		Stir-baking with vinegar	0.036↑
		Stir-baking with rice wine	0.044↑
12	Berberine hydrochloride	None	0.128	[13]
		Stir-baking with vinegar	0.120↓
		Stir-baking with rice wine	0.118↓
13	Columbamine	None	0.262	[13]
		Stir-baking with vinegar	0.068↑
14	Palmatine hydrochloride	None	0.282	[13]
		Stir-baking with vinegar	0.120↓
		Stir-baking with vinegar	1.177↑
15	Liposoluble components	None	0.932	[9]
		Stir-baking with vinegar	0.711↓

PubChemCID: protopine: 4970; α-allocryptopine: 98570; tetrahydrocolumbamine: 440229; coptisine: 72322; palmatine: 19009; berberine: 2353; dehydrocorydaline: 34781; tetrahydroberberine: 34458; corydaline: 10130; tetrahydrocoptisine: 6770; berberine hydrochloride: 12456; columbamine: 72310; palmatine hydrochloride: 73442. CAS registry number: D, L-tetrahydropalmatine: 10097-84-4 (↑ denotes that the content of corresponding compounds increased compared with the raw C. yanhusuo; ↓ denotes that the content of corresponding compounds decreased compared with the raw C. yanhusuo).