Liu Wei Di Huang Wan and the Delay of Insulin Use in Patients with Type 2 Diabetes in Taiwan: A Nationwide Study

Table 6

Hazard of insulin use in statin users of TCM including LWDHW estimated using cox proportional hazards model with National Health Insurance Research Database in Taiwan, 2000–2012.

Herbal product usage	Case/population	aHR (95% CI)	aHR (95% CI)
Total statin users	6,881/34,924
Stratified by dose (g)
Never used	2,885/14,189	Reference
CHPs without LWDHW	2,165/11,266	0.69 (0.65–0.73)	Reference
LWDHW < 36	43/2,209	0.63 (0.57–0.70)	0.91 (0.82–1.01)
36 ≤ LWDHW < 90	508/2,468	0.65 (0.59–0.72)	0.93 (0.85–1.03)
90 ≤ LWDHW < 265	472/2,417	0.61 (0.56–0.68)	0.88 (0.79–0.97)
LWDHW ≥ 265	416/2,375	0.52 (0.47–0.58)	0.74 (0.66–0.82)
Stratified by time (days)
Never used	2,885/14,189	Reference
CHPs without LWDHW	2,165/11,266	0.69 (0.65–0.73)	Reference
LWDHW < 7	314/1,403	0.69 (0.61–0.77)	0.98 (0.87–1.10)
7 ≤ LWDHW < 21	666/3,307	0.64 (0.59–0.70)	0.92 (0.84–1.00)
21 ≤ LWDHW < 60	447/2,401	0.60 (0.54–0.66)	0.86 (0.77–0.95)
LWDHW ≥ 60	404/2,358	0.51 (0.46–0.57)	0.72 (0.65–0.80)

Adjusted for sex, age, comorbidity, and number of antidiabetics.