Liu Wei Di Huang Wan and the Delay of Insulin Use in Patients with Type 2 Diabetes in Taiwan: A Nationwide Study

Table 7

Hazard of insulin use in statin users of TCM including Fang Ji as control estimated using cox proportional hazards model with National Health Insurance Research Database in Taiwan, 2000–2012.

Herbal product usage	Case/population	aHR (95% CI)	aHR (95% CI)
Total statin users	6,881/34,924
Stratified by dose (g)
Never used	2,885/14,189	Reference
CHPs without Fanɡ Ji	3,924/20,371	0.65 (0.62–0.68)	Reference
Fanɡ Ji < 6	12/50	0.69 (0.39–1.21)	1.04 (0.59–1.83)
6 ≤ Fanɡ Ji < 10.5	21/120	0.49 (0.32–0.75)	0.74 (0.48–1.13)
10.5 ≤ Fanɡ Ji < 26	19/93	0.63 (0.40–0.99)	0.96 (0.61–1.51)
Fanɡ Ji ≥ 26	20/101	0.60 (0.39–0.93)	0.92 (0.60–1.43)
Stratified by time (days)
Never used	2,885/14,189	Reference
CHPs without Fanɡ Ji	3,924/20,371	0.65 (0.62–0.68)	Reference
Fanɡ Ji < 6	5/33	0.41 (0.17–0.98)	0.62 (0.26–1.49)
6 ≤ Fanɡ Ji < 9	29/146	0.55 (0.38–0.79)	0.83 (0.58–1.20)
9 ≤ Fanɡ Ji < 21	17/81	0.66 (0.41–1.06)	1.01 (0.63–1.63)
Fanɡ Ji ≥ 21	21/104	0.63 (0.41–0.96)	0.97 (0.63–1.48)

Adjusted for sex, age, comorbidity, and number of antidiabetics.