Luteolin Improves Cyclophosphamide-Induced Cystitis through TXNIP/NLRP3 and NF-κB Pathways

Figure 1

Effect of LUT on the pathological morphology of the bladder tissue in CYP-induced cystitis. (a) The chemical structure of LUT (3,4,5,7-hydroxyl-flavone). (b) Bladder microstructure from four groups of rats. In the CYP group, the bladder structure was severely damaged, with obvious bleeding, edema, and inflammatory cell infiltration. The shape of the bladder in the CYP + LUT group was close to normal. Arrows indicate bleeding, ∗ indicates edema, and # indicates infiltration of inflammatory cells. (c) Inflammation score under HE staining of the bladder in each group (n = 5). (d) The difference in the wet bladder weight between different groups (n = 6). and ; NS: not significant.

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