Luteolin Improves Cyclophosphamide-Induced Cystitis through TXNIP/NLRP3 and NF-κB Pathways

Figure 2

LUT inhibits the increase in oxidative stress and inflammatory cytokine levels in the bladder tissue caused by CYP. The measurement results of MDA (a), GSH (b), and SOD (c) levels in the bladder of each group. LUT treatment reduced the disorder of bladder oxidative stress-related molecules caused by CYP. (d) The expressions of IL-1β, IL-6, and TNF-α in the bladder of four groups were detected by western blot. LUT inhibited the upregulation of inflammatory factors induced by CYP. The expression analysis of IL-1β (e), IL-6 (f), and TNF-α (g) protein in the bladder of four groups (n = 6). , , and ; NS: not significant.

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