Nonclinical Safety Pharmacology Study of the Herbal Product HAD-B1

Table 3

Effects of HAD-B1 on body temperature in rats.

Sex	Groups	Dose (mg/kg)	Time (hr)
			0	1	2	4	6	24
Males	Control	0	38.2 ± 0.1	38.3 ± 0.2	38.0 ± 0.2	37.7 ± 0.2	37.6 ± 0.2	38.1 ± 0.2
	T1	500	38.3 ± 0.3	38.3 ± 0.3	38.0 ± 0.3	37.8 ± 0.3	37.6 ± 0.2	38.2 ± 0.3
	T2	1000	38.3 ± 0.3	38.3 ± 0.4	38.0 ± 0.4	37.8 ± 0.2	37.6 ± 0.2	38.1 ± 0.3
	T3	2000	38.3 ± 0.2	38.1 ± 0.2	37.8 ± 0.1	37.7 ± 0.2	37.6 ± 0.2	38.0 ± 0.2
Females	Control	0	38.8 ± 0.3	39.0 ± 0.2	38.9 ± 0.2	38.2 ± 0.2	37.9 ± 0.2	38.7 ± 0.2
	T1	500	39.0 ± 0.3	39.0 ± 0.2	38.9 ± 0.3	38.2 ± 0.3	37.9 ± 0.2	38.8 ± 0.3
	T2	1000	38.9 ± 0.4	38.8 ± 0.2	38.7 ± 0.2^+	38.0 ± 0.2	37.8 ± 0.1	38.6 ± 0.4
	T3	2000	38.9 ± 0.2	38.9 ± 0.2	38.7 ± 0.2	38.0 ± 0.2	37.8 ± 0.2	38.8 ± 0.3

Note. Data described as the mean ± S.D. (n = 8).