Nonclinical Safety Pharmacology Study of the Herbal Product HAD-B1

Table 4

Effects of HAD-B1 on respiratory rate in rats.

Groups	Dose (mg/kg)	Time (hr)
		0	1	2	4	6	24
Control	0	155.56 ± 55.73	125.67 ± 14.02	126.43 ± 8.28	126.47 ± 6.28	149.68 ± 68.76	132.99 ± 7.04
T1	500	141.64 ± 42.61	126.89 ± 12.44	130.36 ± 11.82	124.55 ± 10.93	127.97 ± 15.24	160.23 ± 58.23
T2	1000	134.15 ± 11.60	143.62 ± 30.75	143.15 ± 41.28	127.56 ± 17.29	151.21 ± 92.61	158.51 ± 37.51
T3	2000	150.02 ± 39.22	140.23 ± 13.25	167.29 ± 56.98	129.05 ± 14.71	147.20 ± 32.46	141.01 ± 23.54

Note. Data described as the mean ± S.D. (n = 8).