Huanglian Jiedu Decoction Exerts Antipyretic Effect by Inhibiting MAPK Signaling Pathway

Figure 2

Effect of HLJDD on serum and hypothalamus tissue biochemical indexes of fever rats. (a-b) Expression of TNF-α and IL-6 in serum of fever rats. (c-d) Expression of PGE₂ and cAMP in hypothalamus tissue of fever rats. <0.01 versus control group. ^##<0.01 versus model group, ^#<0.05 versus model group. Control: as a blank control group; Model: intraperitoneal injection of LPS 100 μg/kg; HLJDD L: HLJDD low dose group (1.58 g/kg); HLJDD M: HLJDD medium dose group (3.15 g/kg); HLJDD H: HLJDD high dose group (6.30 g/kg).

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