Bioflavonoid Galangin Suppresses Hypertrophic Scar Formation by the TGF-β/Smad Signaling Pathway

Figure 1

Gross images of representative scarring samples. (a) On day 15 after wounding, the epithelialization was completed and the HS model was accomplished. (b) After the second injection (day 20), the HSs in group C and D were more softened and had lower protuberant heights. (c) At the end of the injection (day 27), a much more significant effect in the Galangin injection groups was observed. G. A : group A; G. B : group B; G. C : group C; and G. D : group D. (d) A special phenomenon was noticed; after the third injection (day 24), the rabbit ear of group A and group B was slouched (left) and the rabbit ear of group C and D became erected again (right). (e) On day 27, after the injection procedure, the HSs were harvested for further experiments. The numbers 0 to 3 represent group A to D, respectively.

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