Traditional Chinese Medicine Yang-Gan-Wan Alleviated Experimental Hepatic Damage by Inhibiting Oxidation, Inflammation, and Apoptosis in Cell and Mouse Models

Figure 7

Oral YGW treatment effectively alleviated hepatic damage and reduced collagen fiber formation in APAP-treated mice. (a) H&E staining (200x and 400x) revealed normal liver cells in mice given the sham and YGW treatments but damaged liver cells in mice treated with APAP. After NAC, pre-YGW, post-YGW, and pre- and post-YGW treatment, the damaged liver tissue showed varying degrees of repair. (b) Masson’s trichrome staining (200x and 400x) showed collagen fiber formation in the liver tissue of mice treated with APAP (blue color), whereas collagen fiber formation was partly restored in the liver tissue of APAP-treated mice after NAC, pre-YGW, post-YGW, and pre- and post-YGW treatments.

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