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| Reference | Publication year | Location | Subjects and gender | Age, y1 | Design | Intervention type | Duration (wk) | Notes about subjects | Outcome | Outcome2 | Findings |
| Intervention | Control | Intervention | Control |
|
| Farajbakhsh et al. [28] | 2019 | Iran | M: 16
F: 31
S: 24 (7/17)
C: 23 (9/14) | 30–70 y
S: 48.04 ± 7.67
C: 50.17 ± 7.6 | Parallel | Sesame oil (30 ml/d) | Placebo (sunflower oil) | 8 | Patients with metabolic syndrome | FBS
Insulin
HOMA-IR | FBS (mg/dl):
Before: 112.58 ± 29.52
After: 108.3 ± 28.0
Insulin (mU/l):
Before: 8.25 ± 4.21
After: 7.7 ± 3.6
HOMA-IR:
Before: 2.33 ± 1.65
After: 2.1 ± 1.4 | FBS (mg/dl):
Before: 106.9 ± 14.5
After: 106.7 ± 12.8
Insulin (mU/l):
Before: 8.3 ± 6.0
After: 7.3 ± 5.0
HOMA-IR:
Before: 2.14 ± 1.4
After: 2.11 ± 1.2 | Sesame consumption significantly decreased FBS compared to the control group |
|
| Mohammad Shahi et al. [14] | 2016 | Iran | F + M: 48
S: 24
C: 24 | 30–60 y
S: 50 ± 12.3
C: 51.72 ± 12.24 | Parallel | Sesamin capsule (200 mg/d) | Placebo capsules (starch) | 8 | Type 2 diabetes mellitus | FBS
HbA1C
Insulin
HOMA-IR | FBS (mg/dl):
Before: 172.5 ± 53.09
After: 138.59 ± 36.89
HbA1C (%):
Before: 8.28 ± 1.55
After: 7.51 ± 1.14
Insulin (mU/l):
Before: 32.99 ± 9.71
After: 36.78 ± 18.57
HOMA-IR:
Before: 13.24 ± 6.11
After: 12.73 ± 6.32 | FBS (mg/dl):
Before: 145.4 ± 49.53
After: 147.13 ± 54.97
HbA1C (%):
Before: 7.76 ± 1.77
After: 7.83 ± 1.85
Insulin (mU/l):
Before: 40.56 ± 25.35
After: 37.28 ± 18.61
HOMA-IR:
Before: 12.72 ± 6.97
After: 12.19 ± 7.06 | Sesame consumption significantly decreased FBS and HbA1C compared to the control group |
| Aslam et al. [15] | 2018 | Pakistan | F + M: 46
S: 23
C: 23 | 18–60 y | Parallel | Sesame oil (30 ml/d) | Placebo (soybean oil) | 12 | Type 2 diabetes mellitus | FBS
HbA1C
Insulin | FBS (mg/dl):
Before: 189.09 ± 4.42
After: 137.83 ± 3.16
HbA1C (%):
Before: 7.55 ± 0.37
After: 6.96 ± 0.26
Insulin (mU/l):
Before: 12.26 ± 1.24
After: 23.13 ± 1.15 | FBS (mg/dl):
Before: 185.04 ± 6.84
After: 218.14 ± 5.92
HbA1C (%):
Before: 7.55 ± 0.37
After: 8.02 ± 0.37
Insulin (mU/l):
Before: 11.97 ± 0.81
After: 7.93 ± 0.38 | Sesame consumption significantly decreased FBS and HbA1C and increased insulin compared to the control group |
|
| Sankar et al. [16] | 2011 | India | F + M: 42
S: 20
C: 22 | S: 58 ± 3
C: 58 ± 4 | Parallel | Sesame oil (35 g/d) + glibenclamide (5 mg/d) | Glibenclamide (5 mg/d) | 8 | Type 2 diabetes mellitus | FBS
HbA1C | FBS (mg/dl):
Before: 150 ± 5.6
After: 96 ± 4.6
HbA1C (%):
Before: 5.2 ± 0.6
After: 3.02 ± 0.2 | FBS (mg/dl):
Before: 150 ± 6.7
After: 120 ± 5.6
HbA1C (%):
Before: 5.4 ± 0.4
After: 4.22 ± 0.4 | Sesame plus glibenclamide consumption significantly decreased FBS and HbA1C compared to the glibenclamide group |
|
| Sankar et al. [27] | 2006 | India | F + M: 40
S: 40
C: 40 | 45–65 y
S: 56.63 ± 7.3
C: 56.63 ± 7.3 | Crossover | Sesame oil (35 g/d) | Placebo (palm or groundnut oils) | 6 | Type 2 diabetes mellitus + hypertension | FBS
HbA1C | FBS (mg/dl):
Before: 146.4 ± 4.04
After: 127.4 ± 4.2
HbA1C (%):
Before: 5.97 ± 0.5
After: 4.15 ± 0.2 | FBS (mg/dl):
Before: 146.4 ± 4.04
After: 142.5 ± 4.6
HbA1C (%):
Before: 5.97 ± 0.5
After: 5.18 ± 0.26 | Sesame consumption significantly decreased FBS and HbA1C compared to the control group |
|
| Figueiredo et al. [24] | 2008 | Brazil | F: 28
S: 14
C: 14 | 30–65 y | Parallel | Sesame flour (30 g/d) | Control | 8 | Type 2 diabetes mellitus | FBS
HbA1C | FBS (mg/dl):
Before: 148.2 ± 45.2
After: 127 ± 22.3
HbA1C (%):
Before: 8.4 ± 1.3
After: 8 ± 0.9 | FBS (mg/dl):
Before: 129 ± 13.4
After: 121.1 ± 20.8
HbA1C (%):
Before: 8 ± 0.1
After: 8.2 ± 0.8 | There was no significant difference at FBS and HbA1C levels between sesame and control groups |
| Raeisi-Dehkordi et al. [26] | 2020 | Iran | F + M: 95
F: 49
M: 46
S: 92
Ca: 95
S + Ca: 95 | 18–60 y
S: 49.17 ± 0.7
Ca: 49.17 ± 0.7
S + Ca: 49.17 ± 0.7 | Crossover | Sesame oil
Sesame oil + canola oil | Canola oil
Canola oil | 9 | Type 2 diabetes mellitus | FBS
Insulin
HOMA-IR-QUICKI | FBS (mg/dl):
Before: 116.04 ± 2.42
Change: 1.59 ± 2.11
Insulin (mU/l):
Before: 17.01 ± 0.97
Change: −6.0 ± 1.72
HOMA-IR:
Before: 2.28 ± 0.11
Change:−0.72 ± 0.20
FBS (mg/dl):
Before: 116.85 ± 2.74
Change: −2.53 ± 3.26
Insulin (mU/l):
Before: 16.10 ± 0.63
Change: −5.03 ± 1.54
HOMA-IR:
Before: 2.16 ± 0.008
Change: −0.62 ± 0.18
QUICKI:
Before: 0.3 ± 0.002
Change: 0.009 ± 0.003
QUICKI:
Before: 0.31 ± 0.002
Change: 0.009 ± 0.003 | FBS (mg/dl):
Before: 122.64 ± 3.52
Change: 7.72 ± 3.15
Insulin (mU/l):
Before: 17.25 ± 0.74
Change: −2.68 ± 1.36
HOMA-IR:
Before: 2.34 ± 0.1
Change: −0.25 ± 0.17
QUICKI:
Before: 0.3 ± 0.002
Change:−0.002 ± 0.003 | There was no significant difference at FBS, insulin, HOMA-IR, and QUICKI levels between sesame as well as sesame-canola and control groups |
|
| Golzarand et al. [25] | 2013 | Iran | F + M: 36
F:28
M:8
S:20 (16/4)
C:16 (12/4) | S: 50 ± 10
C: 53 ± 9 | Parallel | Grounded sesame seed (28 g/d) | Control | 6 | Type 2 diabetes mellitus | FBS | FBS (mg/dl):
Before: 148 ± 53
After: 137 ± 9.2 | FBS (mg/dl):
Before: 151 ± 52
After: 158 ± 12.3 | There was no significant difference at the FBS level between sesame and control groups |
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