RNA-Seq Analysis Reveals Dendrobium officinale Polysaccharides Inhibit Precancerous Lesions of Gastric Cancer through PER3 and AQP4

Table 3

The upstream regulators’ analysis by IPA in MOD versus DOP group.

Upstream regulator	Predicted activation state	Predicted activation state	Activation z-score	value of overlap	Target molecules in dataset
OSM	Cytokine	Activated	2.036	0.0000824	ECM1, FETUB, GADD45G, GFPT1, IRF7, KRT16, KRT17, LIFR, S100A9
TNF	Cytokine	Activated	2.064	0.0403	FZD5, GADD45G, INSIG1, IRF7, KRT15, LIFR, MET, Mt1, OASL, RNASE1, S100A9
EGF	Growth factor	Activated	2.166	0.0313	GFPT1, KRT15, KRT16, MET, S100A9
CLOCK	Transcription regulator	Activated	2.236	0.00019	CPD, DBP, NR1D1, NR1D2, PER3, TEF
IL10RA	Transmembrane receptor	Inhibited	−2.236	0.00337	CELA1, ECM1, ERO1A, Gstm3, IRF7
SIRT1	Transcription regulator	Inhibited	−2.2	0.00267	CELA1, DBP, ERO1A, GFPT1, IRF7, NR1D1
IL1RN	Cytokine	Inhibited	−2	0.000856	IRF7, LIFR, OASL, S100A9